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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Creatine supplementation spares muscle glycogen during high intensity intermittent exercise in rats

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Autor(es):
Roschel, Hamilton [1] ; Gualano, Bruno [1] ; Marquezi, Marcelo [1] ; Costa, Andre [1] ; Lancha, Jr., Antonio H. [1]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Sch Phys Educ & Sport, Sao Paulo - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION; v. 7, JAN 29 2010.
Citações Web of Science: 16
Resumo

Background: The effects of creatine (CR) supplementation on glycogen content are still debatable. Thus, due to the current lack of clarity, we investigated the effects of CR supplementation on muscle glycogen content after high intensity intermittent exercise in rats. Methods: First, the animals were submitted to a high intensity intermittent maximal swimming exercise protocol to ensure that CR-supplementation was able to delay fatigue ( experiment 1). Then, the CR-mediated glycogen sparing effect was examined using a high intensity intermittent sub-maximal exercise test ( fixed number of bouts; six bouts of 30-second duration interspersed by two-minute rest interval) ( experiment 2). For both experiments, male Wistar rats were given either CR supplementation or placebo (Pl) for 5 days. Results: As expected, CR-supplemented animals were able to exercise for a significant higher number of bouts than Pl. Experiment 2 revealed a higher gastrocnemius glycogen content for the CR vs. the Pl group (33.59%). Additionally, CR animals presented lower blood lactate concentrations throughout the intermittent exercise bouts compared to Pl. No difference was found between groups in soleus glycogen content. Conclusion: The major finding of this study is that CR supplementation was able to spare muscle glycogen during a high intensity intermittent exercise in rats. (AU)

Processo FAPESP: 99/07678-3 - Influência da suplementação de creatina na concentração plasmática de lactato e muscular de glicogênio em ratos submetidos a atividade intermitente supra limiar
Beneficiário:Hamilton Augusto Roschel da Silva
Linha de fomento: Bolsas no Brasil - Mestrado