Effects of Helicobacter pylori Infection on the Ex... - BV FAPESP
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Effects of Helicobacter pylori Infection on the Expressions of Bax and Bcl-2 in Patients with Chronic Gastritis and Gastric Cancer

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Autor(es):
Bartchewsky, Jr., Waldemar [1] ; Martini, Mariana R. [1] ; Squassoni, Aline C. [1] ; Alvarez, Marisa C. [1] ; Ladeira, Marcelo S. P. [2] ; Salvatore, Daisy M. F. [3] ; Trevisan, Miriam A. [4] ; Pedrazzoli, Jr., Jose [1] ; Ribeiro, Marcelo L. [1]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Univ Sao Francisco, Unidade Integrada Farmacol & Gastroenterol, BR-12900000 Braganca Paulista, SP - Brazil
[2] UNESP, Dpto Clin Med, Botucatu, SP - Brazil
[3] UNESP, Dpto Patol, Botucatu, SP - Brazil
[4] Lab MULTIPAT, Campinas, SP - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: Digestive Diseases and Sciences; v. 55, n. 1, p. 111-116, JAN 2010.
Citações Web of Science: 13
Resumo

The aim of the present study is to evaluate the influence of Helicobacter pylori on Bax and Bcl-2 mRNA and protein levels in patients with chronic gastritis and gastric cancer. The study included 217 patients, of which 26 were uninfected; 127 had chronic gastritis and were H. pylori-positive, and 64 had gastric cancer. Bacterial genotypes were evaluated by PCR, and the expression values were determined by quantitative real-time PCR and immunohistochemistry. Our data showed that the up-regulationary effects of H. pylori infection on the proapoptotic gene, Bax, were stronger than its induction of Bcl-2; this effect may increase apoptosis in patients with chronic gastritis. In patients with gastric cancer, the up-regulation of the anti-apoptotic gene, Bcl-2, counteracted the pro-apoptotic effects of Bax, leading to a deregulation of apoptosis-associated gene expression, favoring cell proliferation. Thus, the disturbance in Bax and Bcl-2 balance, induced by H. pylori, might be important in gastric cancer development. (AU)

Processo FAPESP: 05/56736-9 - Estudo das alterações decorrentes da infecção por Helicobacter pylori na gênese do câncer gástrico
Beneficiário:Marcelo Lima Ribeiro
Modalidade de apoio: Auxílio à Pesquisa - Regular