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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Acute benzodiazepine administration induces changes in homocysteine metabolism in young healthy volunteers

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Autor(es):
Pompeia, Sabine [1] ; Grego, Bruno H. C. [1] ; Pradella-Hallinan, Marcia [1] ; Hachul, Helena [1] ; Tufik, Sergio [1] ; D'Almeida, Vania [2]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Dept Psychobiol, BR-04024002 Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Biosci, BR-04024002 Sao Paulo - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo de Revisão
Fonte: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY; v. 33, n. 6, p. 933-938, AUG 31 2009.
Citações Web of Science: 3
Resumo

Purpose: High cortisol plasma concentrations have been shown to be associated with increases in homocysteine levels. Here we studied whether decreases in cortisol concentration, induced by an acute oral dose of a benzodiazepine, could decrease homocysteine, and if changes were similar in both genders. Methods: This was a double-blind, cross-over design study Of acute oral flunitrazepam (1.2 mg) and placebo in young, healthy, male and female (n = 21) volunteers. Blood samples were collected 3 h after ingestion (after peak-plasma concentration of flunitrazepam was reached). Various biochemical parameters were analysed, such as plasma homocysteine, cysteine, folate, vitamins B6, B12, and sexual hormones. Results: Flunitrazepam reduced cortisol (p = 0.0011), cysteine (p = 0.014) and homocysteine (p = 0.028) concentrations, irrespective of gender. No correlations were found between cortisol and other biochemical markers (all r's<0.03). Concentration of cysteine and homocysteine were negatively correlated with plasma flunitrazepam concentration, suggesting that changes in these amino acids might be related to the metabolism of this benzodiazepine. Conclusion: Acute administration of flunitrazepam decreases plasma homocysteine and cysteine by mechanisms that seem unrelated to changes in cortisol. Given the importance of homocysteine as a market of life-threatening disorders, the mechanisms involved in the decrease of these amino acids are potential targets for clinical application. (C) 2009 Elsevier Inc. All rights reserved. (AU)

Processo FAPESP: 05/03552-8 - Efeitos do gênero, estresse psicológico e uso de benzodiazepínicos sobre as concentrações plasmáticas de homocisteína
Beneficiário:Bruno Henrique Do Carmo Grego
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 98/14303-3 - Center for Sleep Studies
Beneficiário:Sergio Tufik
Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
Processo FAPESP: 03/00046-9 - Efeitos cognitivos atípicos do benzodiazepínico lorazepam
Beneficiário:Sabine Pompéia
Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores