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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Adult partner preference and sexual behavior of male rats exposed prenatally to betamethasone

Texto completo
Piffer, Renata C. [1] ; Garcia, Patricia C. [1] ; Pereira, Oduvaldo C. M. [1]
Número total de Autores: 3
Afiliação do(s) autor(es):
[1] Sao Paula State Univ, UNESP, Inst Biosci, Dept Pharmacol, BR-18618000 Sao Paulo - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: Physiology & Behavior; v. 98, n. 1-2, p. 163-167, AUG 4 2009.
Citações Web of Science: 16

The aim of this Study was to investigate long-term effects of prenatal betamethasone exposure oil sexual partner preference, testosterone level, and sexual behavior. Pregnant rats received 0.1 mg/kg of betamethasone or saline on the 12th, 13th, 18th, and 19th days of pregnancy. Parameters in male offspring were evaluated at 90 days of age. Male rats from the betamethasone group did not show any difference in sexual partner preference as expressed by the total number of visits to the female or male zone. However, these males spent significantly less total time and shorter duration per visit in the female zone than their controls. Therefore, prenatal exposure to betamethasone led to a significantly lower sexual female partner preference score compared to the control group. These animals also presented diminished testosterone levels in adulthood. Prenatal exposure to betamethasone induced a delay in the latency to first ejaculation. as well as a decrease in the numbers of postejaculatory intromissions, total intromissions and total ejaculations. Although 80% of the betamethasone-treated animals exhibited male Sexual behavior, when they were castrated and pretreated with estrogen, 50% of them showed lordosis and accepted mounts of another sexually experienced male. These results suggest that the prenatal treatment with betamethasone, by increasing maternal corticosteroid level, may have diminished testosterone peak in male pups, a peak crucial to brain sexual differentiation. As a consequence, the prenatal betamethasone treatment reduced the testosterone level in adulthood and altered partner preference and Sexual behavior. (C) 2009 Elsevier Inc. All rights reserved. (AU)

Processo FAPESP: 06/57038-6 - Influencia da exposicao pre-natal a betametasona sobre o desenvolvimento da prole, do nascimento a vida adulta reproudutiva, em ratos.
Beneficiário:Oduvaldo Câmara Marques Pereira
Linha de fomento: Auxílio à Pesquisa - Regular