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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Acute cognitive effects of donepezil in young, healthy volunteers

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Autor(es):
Zaninotto, Ana L. C. [1] ; Bueno, Orlando F. A. [1] ; Pradella-Hallinan, Marcia [1] ; Tufik, Sergio [1] ; Rusted, Jenny [2] ; Stough, Con [3] ; Pompeia, Sabine [1]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, UNIFESP, Dept Psicobiol, BR-04024002 Sao Paulo - Brazil
[2] Univ Sussex, Dept Psychol, Brighton, BN - England
[3] Swinburne Univ Technol, Brain Sci Inst, Melbourne, Vic - Australia
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL; v. 24, n. 6, p. 453-464, AUG 2009.
Citações Web of Science: 21
Resumo

Objective The acute nootropic potential of donepezil in young healthy volunteers has not been adequately investigated mainly because in previous studies: (1) effects were assessed before peak-plasma concentration (Tmax) was reached; (2) only a few cognitive processes were assessed. Here we investigated a myriad of cognitive effects of augmentation of acetylcholine using an acute dose of donepezil in healthy adults at theoretical Tmax. Methods This was a double-blind, placebo controlled, parallel group design study of cognitive effects of acute oral donepezil (5 mg). Subjects were tested twice after donepezil ingestion: 90 min (time that coincides with previous testing in the literature) and 210 min. (theoretical Tmax). The test battery included tasks that tap cognitive domains that are sensitive to acetylcholine manipulations. Results At both testing times donepezil improved long-term recall of prose, objects recall, recall of spatial locations, and integration of objects with their locations, some effects having been related to self-reported mood enhancement. However, improvement of performance in the central executive measure (backward digit span) occurred only at Tmax. Conclusion Positive cognitive effects of acute donepezil can be observed in various cognitive domains including mood, but its full nootropic potential is more clearly found close to theoretical peak-plasma concentration. Copyright (C) 2009 John Wiley \& Sons, Ltd. (AU)

Processo FAPESP: 98/14303-3 - Center for Sleep Studies
Beneficiário:Sergio Tufik
Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs