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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Modeling stochastic Ca2+ release from a cluster of IP3-sensitive receptors

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Autor(es):
Diambra, Luis ; Guisoni, Nara Cristina [2]
Número total de Autores: 2
Tipo de documento: Artigo Científico
Fonte: Cell Calcium; v. 37, n. 4, p. 321-332, Apr. 2005.
Área do conhecimento: Ciências Biológicas - Biofísica
Assunto(s):Biofísica   Processos estocásticos
Resumo

We focused our attention on Ca2+ release from the endoplasmic reticulum through a cluster of inositol(1,4,5)-trisphosphate (IP3) receptor channels. The random opening and closing of these receptors introduce stochastic effects that have been observed experimentally. Here, we present a stochastic version of Othmer-Tang model (OTM) for IP3 receptor clusters. We address the average behavior of the channels in response to IP3 stimuli. In our stochastic simulation we found that the fraction of open channels versus [IP3] follows a Hill curve, whose associate Hill coefficient increases when intracellular Ca2+ level increase. This finding suggests that feedback from cytosolic Ca2+ plays a key role in the channel response to IP3. We also study several aspects of the stochastic properties of Ca2+ release and we compare with experimental observations. (AU)

Processo FAPESP: 03/00831-8 - Modelos estocásticos para processos de transporte em células
Beneficiário:Nara Cristina Guisoni
Linha de fomento: Bolsas no Brasil - Pós-Doutorado