Antioxidant flavan-3-ols and flavonol glycosides from Maytenus aquifolium

Autor(es)

Corsino‚ J. ; Silva‚ D. H. S. ; Zanoni‚ M. V. B. ; Bolzani‚ V. S. ; França‚ S. C. ; Pereira‚ A. M. S. ; Furlan‚ M.

• Tipo de documento: Artigo Científico
• Fonte: Phytotherapy Research; v. 17, n. 8, p. 913-916, 2003.
• Área do conhecimento: Ciências Exatas e da Terra - Química
• Assunto(s): Antioxidantes Flavonoides Glicosídeos Celastraceae Maytenus Voltametria Radicais livres

Resumo

TLC autographic assay revealed, in the EtOAc extract obtained from leaves and root bark of Maytenus aquifolium (Celastraceae), the presence of five compounds exhibiting antioxidant properties towards β-carotene. They were isolated and identified as epigallocatechin (1), (+) ouratea-catechin (2), proanthocyanidin (3), kaempferol 3-O-α-L-rhamnopyranosyl (1[RIGHTWARDS ARROW]6)-O-[β-D-glucopyranosyl (1[RIGHTWARDS ARROW]3)-O-α-L-rhamnopyranosyl-(1[RIGHTWARDS ARROW]2)]-O-β-D-glucopyranosyl (4) and quercetin 3-O-α-L-rhamnopyranosyl (1[RIGHTWARDS ARROW]6)-O-[β-D-glucopyranosyl (1[RIGHTWARDS ARROW]3)-O-α-L-rhamnopyranosyl-(1[RIGHTWARDS ARROW]2)]-O-β-D-glucopyranosyl (5). The isolates were investigated for their redox properties using cyclic voltammetry and for their radical scavenging abilities through spectrophotometric assay on the reduction of 2,2-diphenyl-pycryl hydrazyl (DPPH). These results were correlated to the inhibition of β-carotene bleaching on TLC autographic assay and to structural features of the flavonoids. Copyright © 2003 John Wiley & Sons, Ltd. (AU)

• Processo FAPESP: 97/10184-7 - Estudo químico e biossintético em espécies de Celastraceae e Hippocrateaceae
• Beneficiário: Maysa Furlan
• Linha de fomento: Auxílio à Pesquisa - Regular
• Processo FAPESP: 98/05074-0 - Conservação e uso sustentável da biodiversidade vegetal do Cerrado e da Mata Atlântica: diversidade química e prospecção de medicamentos potenciais
• Beneficiário: Vanderlan da Silva Bolzani
• Linha de fomento: Auxílio à Pesquisa - Programa BIOTA - Temático