Exercise training associated with estrogen therapy induced cardiovascular benefits after ovarian hormones deprivation

Autor(es)

Flues, Karin ^[1] ; Paulini, Janaina ^[1] ; Brito, Sebastiao ^[2] ; Sanches, Iris Callado ^[2] ; Consolim-Colombo, Fernanda ^[1] ; Irigoyen, Maria-Claudia ^[1] ; De Angelis, Katia ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Med, Heart Inst InCor, Hypertens Unit, Sao Paulo - Brazil

^[2] Univ Sao Judas Tadeu, Human Movement Lab, BR-03166000 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: MATURITAS; v. 65, n. 3, p. 267-271, 2010.
• Citações Web of Science: 31

Resumo

Menopause is recognized as a period of increased risk for coronary heart disease. Although the benefits of exercise training in lowering cardiovascular risk factors are well established, the risks and benefits of hormone therapy have been questioned. The purpose of the present study was to investigate the effects of estrogen therapy (HT) associated or not with exercise training (ET) in autonomic cardiovascular control in ovariectomized (OVX) rats. Female rats were divided into: control, OVX, OVX+HT, OVX+ET and OVX+HT+ET. HT was performed using a 0.25 mg 8-weeks sustained release pellet. Trained groups were submitted to an 8-week exercise training protocol on treadmill. Baroreflex sensitivity (BRS) was evaluated by heart rate responses to arterial pressure (AP) changes, and vagal and sympathetic tonus by pharmacological blockade. Ovariectomy induced an AP increase (123 +/- 2 mmHg vs. 108 +/- 2 mmHg), BRS impairment (similar to 69%), sympathetic activation (similar to 100%) and vagal tonus reduction (similar to 77%) compared to controls. HT or ET normalized the changes in parasympathetic tonus. However, only the association HT + ET was able to promote normalization of AP, BRS and sympathetic tonus, as compared to controls. These results indicate that ET induces cardiovascular and autonomic benefits in OVX rats under HT, suggesting a positive role of this association in the management of cardiovascular risk factor in postmenopausal women. (C) 2009 Elsevier Ireland Ltd. All rights reserved. (AU)

• Processo FAPESP: 09/06865-8 - Efeitos do treinamento físico e da reposição hormonal no controle cardiovascular em um modelo experimental de menopausa: papel do estresse oxidativo
• Beneficiário: Sebastião de Brito
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 07/57595-5 - Efeitos do treinamento físico no controle autônomo cardiovascular em fêmeas saudáveis e submetidas à privação dos hormônios ovarianos: papel do estresse oxidativo
• Beneficiário: Kátia de Angelis Lobo D Avila
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores