Cardiovascular effects of acetylcholine microinjection into the ventrolateral and dorsal periaqueductal gray of rats

Autor(es)

Deolindo‚ M.V. ; Pelosi‚ G.G. ; Busnardo‚ C. ; Resstel‚ L.B.M. ; Corrêa‚ F.M.A.

• Tipo de documento: Artigo Científico
• Fonte: Brain Research; v. 1371, p. 74-81, 2011.

Resumo

In the present study, we describe the cardiovascular effects of local acetylcholine (Ach) microinjection into both the ventrolateral (vlPAG) and dorsal (dPAG) periaqueductal gray areas of anesthetized rats and the possible local receptors involved with these responses. Microinjection of Ach (9, 27, 45 or 81 nmol/50 nL) into the vlPAG caused dose-related depressor responses. These hypotensive responses were blocked by local pretreatment with increasing doses of the nonselective muscarinic antagonist atropine (1, 3 or 9 nmol/50 nL). The microinjection of Ach into the dPAG caused no significant cardiovascular responses in anesthetized rats. In conclusion, the present findings suggest that a cholinergic system present in the vlPAG, but not in the dPAG, is involved with cardiovascular system control. Moreover, these cardiovascular responses evoked by Ach are mediated by muscarinic receptors. (C) 2010 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 09/05308-8 - Função do núcleo paraventricular do hipotálamo na resposta cardiovascular e neuroendócrina observada em ratos submetidos ao estresse por restrição
• Beneficiário: Cristiane Busnardo Santiago
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 07/50166-1 - Efeito da estimulação colinérgica na substância cinzenta periaquedutal no controle do sistema cardiovascular de ratos
• Beneficiário: Milena Deolindo Vieira
• Modalidade de apoio: Bolsas no Brasil - Doutorado