Chemical, spectroscopic characterization, DFT studies and antibacterial activities in vitro of a new gold(I) complex with rimantadine

Autor(es)

Sucena, Suelen F. ^[1] ; Paiva, Raphael E. F. ^[1] ; Abbehausen, Camilla ^[1] ; Mattos, Ives B. ^[2] ; Lancellotti, Marcelo ^[2] ; Formiga, Andre L. B. ^[3] ; Corbi, Pedro P. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Campinas UNICAMP, Inst Chem, Bioinorgan & Med Chem Res Lab, BR-13083970 Sao Paulo - Brazil

^[2] Univ Campinas UNICAMP, Inst Biol, Biotechnol Lab, BR-13083970 Sao Paulo - Brazil

^[3] Univ Campinas UNICAMP, Inst Chem, Coordinat Chem Lab, BR-13083970 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY; v. 89, p. 114-118, APR 2012.
• Citações Web of Science: 3

Resumo

A novel gold(I) complex with rimantadine (RTD) was obtained and structurally characterized by a set of chemical and spectroscopic analysis. H-1, C-13 and N-15 nuclear magnetic resonance (NMR) and infrared (IR) spectroscopic measurements suggest coordination of the ligand to Au(I) through the N atom of the ethanamine group. Theoretical (DFT) calculations confirmed the IR assignments and permit proposing an optimized geometry for the complex. The gold(I)-rimantadine complex (Au-RTD) is soluble in methanol, ethanol, dimethylsulfoxide, acetone and acetonitrile. The preliminary kinetic studies based on UV-vis spectroscopic measurements indicate the stability of the compound in solution. Antibacterial activities of the complex were evaluated by an antibiogram assay. The Au-RTD complex showed an effective in vitro antibacterial activity against the Pseudomonas aeruginosa, Escherichia coli (Gram-negative), and Staphylococcus aureus (Gram-positive) bacterial strains. (C) 2011 Elsevier BM. All rights reserved. (AU)

• Processo FAPESP: 06/55367-2 - Complexos metálicos de platina (II), platina (IV), paládio (II), ouro (I) e ouro (III) com aminoácidos e derivados: síntese, caracterização e aplicações farmacológicas
• Beneficiário: Pedro Paulo Corbi
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 08/56777-5 - Estudo molecular e profilático das bactérias naturalmente transformaveis do trato respiratório humano - Haemophilus influenzae, Neisseria meningitidis e Streptococcus pneumoniae
• Beneficiário: Marcelo Lancellotti
• Modalidade de apoio: Auxílio à Pesquisa - Regular