Pyridine Alkaloids from Senna multijuga As Acetylcholinesterase Inhibitors

Autor(es)

Francisco, Welington ^[1] ; Pivatto, Marcos ^{[1, 2]} ; Danuello, Amanda ^{[2, 1]} ; Regasini, Luis O. ^[1] ; Baccini, Luciene R. ^[1] ; Young, Maria C. M. ^[3] ; Lopes, Norberto P. ^[2] ; Lopes, Joao L. C. ^[2] ; Bolzani, Vanderlan S. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista UNESP, Inst Quim, Dept Quim Organica, Nucleo Bioensaios Biossintese & Ecofisiol Prod Na, BR-14801970 Araraquara, SP - Brazil

^[2] USP, Fac Ciencias Farmaceuticas Ribeirao Preto, BR-14040903 Ribeirao Preto, SP - Brazil

^[3] Inst Bot IBt, Sec Fisiol & Bioquim Plantas, BR-01061970 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Natural Products; v. 75, n. 3, p. 408-413, MAR 2012.
• Citações Web of Science: 13

Resumo

As part of an ongoing research project on Senna and Cassia species, five new pyridine alkaloids, namely, 12'-hydroxy-7'-multijuguinol (1), 12'-hydroxy-8'-multijuguinol (2), methyl multijuguinate (3), 7'-multijuguinol (4), and 8'-multijuguinol (5), were isolated from the leaves of Senna multijuga (syn. Cassia multijuga). Their structures were elucidated on the basis of spectroscopic data analysis. Mass spectrometry was used for confirmation of the positions of the hydroxy groups in the side-chains of 1, 2, 4, and 5. All compounds exhibited weak in vitro acetylcholinesterase inhibitory activity as compared with the standard compound physostigmine. (AU)

• Processo FAPESP: 03/02176-7 - Conservação e uso sustentável da diversidade do Cerrado e da Mata Atlântica: diversidade química e prospecção de medicamentos potenciais - fase II
• Beneficiário: Vanderlan da Silva Bolzani
• Linha de fomento: Auxílio à Pesquisa - Programa BIOTA - Temático