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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Paradoxical sleep deprivation induces muscle atrophy

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Autor(es):
Dattilo, Murilo [1, 2] ; Moreira Antunes, Hanna Karen [2, 3] ; Medeiros, Alessandra [3] ; Monico-neto, Marcos [2] ; Souza, Helton de S. A. [2] ; Lee, Kil Sun [4] ; Tufik, Sergio [1] ; de Mello, Marco Tulio [1, 2]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Dept Psicobiol, BR-04020050 Sao Paulo - Brazil
[2] CEPE, Sao Paulo - Brazil
[3] Univ Fed Sao Paulo, Dept Biociencias, Santos - Brazil
[4] Univ Fed Sao Paulo, Dept Bioquim, BR-04020050 Sao Paulo - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: MUSCLE & NERVE; v. 45, n. 3, p. 431-433, MAR 2012.
Citações Web of Science: 21
Resumo

Introduction: Because paradoxical sleep deprivation (PSD) induces a catabolic hormone profile, we sought to evaluate the morphology of the tibialis anterior (TA) muscle and testosterone and corticosterone levels of paradoxical sleepdeprived rats.Methods: Three study groups of rats were established: the first group was sleep deprived for 96 h; the second group was also sleep deprived for 96 h, but then returned to their home-cage and allowed to sleep for the next 96 h; and the third group was the control group, with a normal sleep cycle. Results: PSD reduced the weight and fiber cross-sectional area of the TA muscle. Moreover, PSD enhanced plasma corticosterone and reduced serum testosterone levels. The 96 h of sleep after PSD was sufficient to restore partially the morphology of TA, while hormones returned to basal levels. Conclusion: PSD induces hormonal alterations that may mediate muscle atrophy. Muscle Nerve, 2012 (AU)

Processo FAPESP: 98/14303-3 - Center for Sleep Studies
Beneficiário:Sergio Tufik
Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
Processo FAPESP: 09/11056-1 - Efeitos da privação de sono no processo de recuperação muscular
Beneficiário:Murilo Dattilo
Linha de fomento: Bolsas no Brasil - Mestrado