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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Primary antiphospholipid syndrome: morphofunctional penile abnormalities with normal sperm analysis

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Autor(es):
Rabelo-Junior, C. N. ; Freire de Carvalho, J. ; Lopes Gallinaro, A. ; Bonfa, E. ; Cocuzza, M. [1] ; Saito, O. [2] ; Silva, C. A. [3, 4]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Dept Urol, Fac Med, BR-01246903 Sao Paulo - Brazil
[2] Univ Sao Paulo, Dept Radiol, Fac Med, BR-01246903 Sao Paulo - Brazil
[3] Univ Sao Paulo, Disciplina Reumatol, Fac Med, Div Rheumatol, BR-01246903 Sao Paulo - Brazil
[4] Univ Sao Paulo, Pediat Rheumatol Unit, Fac Med, BR-01246903 Sao Paulo - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: Lupus; v. 21, n. 3, p. 251-256, MAR 2012.
Citações Web of Science: 7
Resumo

Objective: To perform a global gonadal and sexual functions assessment in primary antiphospholipid syndrome (PAPS) patients. Methods: A cross-sectional study was conducted in 12 male PAPS patients and 20 healthy controls. They were assessed by demographic data, clinical features, systematic urological examination, sexual function, testicular ultrasound, seminal parameters according to the World Health Organization (WHO), seminal sperm antibodies, and hormone profile, including follicle stimulating hormone (FSH), luteinizing hormone (LH), morning total testosterone, and thyroid hormones. Results: The median of current age and age of spermarche were similar in PAPS patients and controls (37.5 vs. 32.4 years, p = 0.270, and 13.1 vs. 12.85 years, p = 0.224, respectively), with a higher frequency of erectile dysfunction in the former group (25% vs. 0%, p = 0.044). Further analysis of PAPS patients with and without previous arterial thrombosis demonstrated that the median penis circumference was significantly lower in PAPS with arterial thrombosis than in PAPS without this complication (8.1 {[}6-10] vs. 10.2 {[}10-11] cm, p = 0.007). In addition, the median penis circumference was significantly lower in PAPS patients with erectile dysfunction than in patients without this complication (7.5 {[}6-9.5] vs. 9.5 {[}7.5-11] cm, p = 0.039). Regarding seminal analysis, the median sperm concentration, sperm motility, and normal sperm forms by WHO guidelines were comparable in PAPS patients and controls (141.5 {[}33-575] vs. 120.06 {[}34.5-329] x 106/ml, p = 0.65; 61.29 {[}25-80] vs. 65.42 {[}43-82]%, p = 0.4; 21.12 {[}10-42.5] vs. 23.95 {[}10-45]%, p = 0.45, respectively), and none of them had oligo/azoospermia. No differences were observed between PAPS patients and controls regarding the frequency of antisperm antibodies, testicular volume by ultrasound, or hormone profile (FSH, LH, morning total testosterone, and thyroid hormone) (p > 0.05). Conclusions: Normal testicular function has been identified in PAPS patients, in spite of morphofunctional penile abnormalities. Previous arterial thrombosis may underlie penile anthropometry alteration. Lupus (2012) 21, 251-256. (AU)

Processo FAPESP: 05/56482-7 - Avaliação da função gonadal em pacientes do sexo masculino com dermatomiosite e polimiosite
Beneficiário:Clovis Artur Almeida da Silva
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 04/07832-2 - Avaliação da função gonadal em pacientes do sexo masculino com lúpus eritematoso sistêmico
Beneficiário:Clovis Artur Almeida da Silva
Linha de fomento: Auxílio à Pesquisa - Regular