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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Obese adolescents with eating disorders: Analysis of metabolic and inflammatory states

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Autor(es):
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Carnier, June [1, 2] ; Sanches, Priscila de Lima [1, 2] ; da Silva, Patricia Leao [2, 1] ; de Piano, Aline [1, 2] ; Tock, Lian [2, 1] ; Campos, Raquel M. S. [2, 1] ; Corgosinho, Flavia C. [1, 2] ; Correa, Fabiola Alvise [1, 2] ; Masquio, Deborah [2, 1] ; Oller do Nascimento, Claudia Maria [1, 3] ; Oyama, Lila Missae [3, 1] ; Ernandes, Regina H. [4] ; de Mello, Marco Tulio [1, 5] ; Tufik, Sergio [5, 1] ; Damaso, Ana R. [1, 2, 6, 7]
Número total de Autores: 15
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, UNIFESP, Sao Paulo - Brazil
[2] Posgrad Program Nutr, Sao Paulo - Brazil
[3] Dept Physiol, Sao Paulo - Brazil
[4] Assoc Found Incent Res, Sao Paulo - Brazil
[5] Dept Psychobiol, Sao Paulo - Brazil
[6] Dept Biosci, Sao Paulo - Brazil
[7] Posgrad Program Interdisciplinary Hlth Sci, Sao Paulo - Brazil
Número total de Afiliações: 7
Tipo de documento: Artigo Científico
Fonte: Physiology & Behavior; v. 105, n. 2, p. 175-180, JAN 18 2012.
Citações Web of Science: 6
Resumo

Objective: The purpose of the present investigation was to compare the effect of interdisciplinary therapy on the physical and metabolic profiles, including body composition, insulin resistance and sensitivity as well as adiponectin and leptin concentrations, of obese adolescents with and without eating disorder symptoms. Methods: A total of 83 obese adolescents (28 with and 55 without eating disorder symptoms) were enrolled for 1 year of interdisciplinary weight-loss therapy (clinical, nutritional, exercise, physiotherapy and psychological). Bulimic and binge eating symptoms were measured by the Bulimic Investigatory Test, Edinburgh. and the Binge Eating Scale, respectively. Leptin and adiponectin concentrations were measured with enzyme-linked immunosorbent assay kits. Visceral and subcutaneous fat were assessed by ultrasonography. Results: Both groups demonstrated improved body mass, body mass index, body fat (%), lean mass, visceral fat, subcutaneous fat, homeostasis model assessment insulin-resistance index (HOMA-IR), quantitative insulin sensitivity check index, total cholesterol, LDL-cholesterol, VLDL, triglycerides, adiponectin and leptin concentrations after therapy. We found a positive correlation between leptin concentrations and subcutaneous fat in the control group and a negative correlation between adiponectin concentrations and HOMA-IR and fat mass (%). The prevalence of obese adolescents with eating disorders was reduced by 89% after 1 year of interdisciplinary therapy. Conclusion: The eating disorder symptoms did not impair the metabolic state during weight loss therapy of obese adolescents. Additionally, long-term interdisciplinary therapy was effective in reducing the chances of developing several co-morbidities in both groups. (C) 2011 Elsevier Inc. All rights reserved. (AU)

Processo FAPESP: 08/53069-0 - Efeitos do tratamento multidisciplinar em adolescentes obesos com esteatose hepática não alcoólica e sua relação com as adipocitocinas pró e anti-inflamatórias
Beneficiário:Ana Raimunda Dâmaso
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 11/50356-0 - Análise de complemento protéico plasmático e de fatores de risco metabólicos em adolescentes obesos em tratamento no Centro de Recuperação e Educação Nutricional (CREN)
Beneficiário:Ana Raimunda Dâmaso
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 06/00684-3 - Fatores orexígenos, anorexígenos, pró e anti-inflamatórios: efeitos do programa multidisciplinar para redução da massa corporal em adolescentes obesos
Beneficiário:Ana Raimunda Dâmaso
Linha de fomento: Auxílio à Pesquisa - Regular