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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Cocaine administration increases angiotensin I-converting enzyme (ACE) expression and activity in the rat striatum and frontal cortex

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Autor(es):
Visniauskas, Bruna [1] ; Perry, Juliana C. [1] ; Oliveira, Vitor [2] ; Dalio, Fernanda M. [2] ; Andersen, Monica L. [1] ; Tufik, Sergio [1] ; Chagas, Jair R. [1, 3]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo UNIFESP, Dept Psicobiol, BR-04024002 Sao Paulo - Brazil
[2] Univ Fed Sao Paulo UNIFESP, Dept Biofis, BR-04039032 Sao Paulo - Brazil
[3] Univ Fed Sao Paulo UNIFESP, Dept Ciencias Saude, BR-11060001 Santos, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: Neuroscience Letters; v. 506, n. 1, p. 84-88, JAN 6 2012.
Citações Web of Science: 3
Resumo

Some central effects of cocaine administration seem to be related to angiotensin II (Ang II) or its metabolites. Nonetheless, it is still an open question whether or not the levels of angiotensin I-converting enzyme (ACE), the main Ang II generating enzyme, are modified by cocaine administration. To evaluate the effect of acute and subchronic cocaine administration on ACE activity and mRNA expression, male rats were randomly assigned to saline or cocaine group. Acute and subchronic cocaine administration induced a significant increase in ACE activity and mRNA expression in the frontal cortex and striatum but not in the hippocampus. These results suggest that some of the Ang II related effects of cocaine upon the central nervous system can be mediated by changes on the expression and activity of ACE in the striatum and frontal cortex. Crown Copyright (C) 2011 Published by Elsevier Ireland Ltd. All rights reserved. (AU)

Processo FAPESP: 98/14303-3 - Center for Sleep Studies
Beneficiário:Sergio Tufik
Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs