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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Implant Osseointegration in Circumferential Bone Defects Treated with Latex-Derived Proteins or Autogenous Bone in Dog's Mandible

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Autor(es):
Manfrin Arnez, Maya Fernanda [1] ; Xavier, Samuel Porfirio [1] ; Pinto Faria, Paulo Esteves [2] ; Pedrosa Junior, Wagner Fernandes [1] ; Cunha, Tatiana Ramirez [3] ; de Mendonca, Ricardo Jose [3] ; Coutinho-Netto, Joaquim [3] ; Salata, Luiz Antonio [1]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Dept Oral & Maxillofacial Surg & Periodont, Fac Dent Ribeirao Preto, BR-14040904 Ribeirao Preto, SP - Brazil
[2] Univ State Sao Paulo, Dept Oral & Maxillofacial Surg, Fac Dent Aracatuba, Sao Paulo - Brazil
[3] Univ Sao Paulo, Dept Biochem & Immunol, Fac Med Ribeirao Preto, BR-14040904 Ribeirao Preto, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH; v. 14, n. 1, p. 135-143, 2012.
Citações Web of Science: 0
Resumo

Background: In sites with diminished bone volume, the osseointegration of dental implants can be compromised. Innovative biomaterials have been developed to aid successful osseointegration outcomes. Purpose: The aim of this study was to evaluate the osteogenic potential of angiogenic latex proteins for improved bone formation and osseointegration of dental implants. Materials and Methods: Ten dogs were submitted to bilateral circumferential defects (5.0 x 6.3 mm) in the mandible. Dental implant (3.3 x 10.0 mm, TiUnite MK3 (TM), Nobel Biocare AB, Goteborg, Sweden) was installed in the center of the defects. The gap was filled either with coagulum (Cg), autogenous bone graft (BG), or latex angiogenic proteins pool (LPP). Five animals were sacrificed after 4 weeks and 12 weeks, respectively. Implant stability was evaluated using resonance frequency analysis (Osstell Mentor T, Osstell AB, Goteborg, Sweden), and bone formation was analyzed by histological and histometric analysis. Results: LPP showed bone regeneration similar to BG and Cg at 4 weeks and 12 weeks, respectively (p >= 3.05). Bone formation, osseointegration, and implant stability improved significantly from 4 to 12 weeks (p <= 2.05). Conclusion: Based on methodological limitations of this study, Cg alone delivers higher bone formation in the defect as compared with BG at 12 weeks; compared with Cg and BG, the treatment with LPP exhibits no advantage in terms of osteogenic potential in this experimental model, although overall osseointegration was not affected by the treatments employed in this study. (AU)

Processo FAPESP: 06/58059-7 - Avaliação da capacidade osseoindutora de proteínas angiogênicas purificadas do látex natural na osseointegração e estabilidade de implantes de titânio: estudo histológico, de RFA, histométrico e análise de fluorescência em mandíbulas de cães
Beneficiário:Maya Fernanda Manfrin Arnez
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 06/04359-0 - Avaliação da capacidade osseoindutora de proteínas angiogênicas derivadas do látex natural na osseointegração e estabilidade de implantes de titânio: estudo histológico, de RFA e histométrico em mandíbula de cães
Beneficiário:Samuel Porfirio Xavier
Linha de fomento: Auxílio à Pesquisa - Regular