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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Interdisciplinary therapy improves biomarkers profile and lung function in asthmatic obese adolescents

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Autor(es):
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da Silva, Patricia Leao [1] ; de Mello, Marco Tulio [2] ; Cheik, Nadia Carla [3] ; Sanches, Priscila Lima [1] ; Correia, Fabiola Alvise [1] ; de Piano, Aline [1] ; Corgosinho, Flavia Campos [1] ; da Silveira Campos, Raquel Munhoz [1] ; do Nascimento, Claudia M. O. [4] ; Oyama, Lila M. [4] ; Tock, Lian [1] ; Tufik, Sergio [2] ; Damaso, Ana R. [5, 1, 6]
Número total de Autores: 13
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Post Grad Program Nutr, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Psychobiol, Sao Paulo - Brazil
[3] Univ Fed Uberlandia, BR-38400 Uberlandia, MG - Brazil
[4] Univ Fed Sao Paulo, Dept Physiol, Sao Paulo - Brazil
[5] Univ Fed Sao Paulo, Dept Biosci, Sao Paulo - Brazil
[6] Univ Fed Sao Paulo, Post Grad Program Interdisciplinary Hlth Sci, Sao Paulo - Brazil
Número total de Afiliações: 6
Tipo de documento: Artigo Científico
Fonte: PEDIATRIC PULMONOLOGY; v. 47, n. 1, p. 8-17, JAN 2012.
Citações Web of Science: 29
Resumo

Background The simultaneous rise in the prevalence of asthma and obesity in the world, have demonstrated the importance of the development of treatment strategies. The purpose of this study was to evaluate the short- and long-term results of interdisciplinary therapy on inflammatory biomarkers and lung function in asthmatics obese adolescents. Methods: Seventy- six post-pubertal obese adolescents were recruited, including 50 non-asthmatics {[}body mass index (BMI), 36 +/- 5 kg/m(2)) and 26 asthmatics (BMI, 39 +/- 4 kg/m(2)). Body composition was measured by plethysmography, and visceral fat was analyzed by ultrasound. Serum levels of adiponectin, leptin, and C-reactive protein (CRP) were analyzed. Asthma and lung function were evaluated according to the American Thoracic Society criteria. Patients were submitted to 1-year weight loss interdisciplinary intervention consisting of medical, nutritional, exercise, and psychological therapy. Results: After interdisciplinary intervention, the lung function and pro/anti-inflammatory adipokines improved significantly in both groups. Most importantly, there was an increase in adiponectin {[}4 (1.86-12.9) to 5.1 (2.48-16)], a reduction in CRP {[}2,073 (385-9,174) to 1,538 (205-7,083)] and leptin concentrations {[}59 (29-69) to 33 (9-49)] in the asthmatics patients. Furthermore, it was observed a reduction in asthma severity after treatment. In addition, Delta adiponectin was an independent factor to improve lung function after therapy in both groups. Conclusions: Interdisciplinary therapy resulted in beneficial changes in inflammatory biomarkers profile and lung function in asthmatic and non-asthmatic obese adolescents. Additionally, for the first time we showed that change in adiponectin level was an independent predictor to improve lung function in Brazilian obese adolescents. Pediatr Pulmonol. 2012; 47: 8-17. (C) 2011 Wiley Periodicals, Inc. (AU)

Processo FAPESP: 98/14303-3 - Center for Sleep Studies
Beneficiário:Sergio Tufik
Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
Processo FAPESP: 06/00684-3 - Fatores orexígenos, anorexígenos, pró e anti-inflamatórios: efeitos do programa multidisciplinar para redução da massa corporal em adolescentes obesos
Beneficiário:Ana Raimunda Dâmaso
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 08/53069-0 - Efeitos do tratamento multidisciplinar em adolescentes obesos com esteatose hepática não alcoólica e sua relação com as adipocitocinas pró e anti-inflamatórias
Beneficiário:Ana Raimunda Dâmaso
Linha de fomento: Auxílio à Pesquisa - Regular