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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Human leukocyte antigen-G 3 ` untranslated region polymorphisms are associated with better kidney allograft acceptance

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Autor(es):
Ciliao Alves, Daiani Cristina [1] ; de Oliveira Crispim, Janaina Cristiana [2] ; Castelli, Erick C. [3] ; Mendes-Junior, Celso Teixeira [4] ; Saloun Deghaide, Neifi Hassan [1] ; Barros Silva, Gyl Eanes [5] ; Costa, Roberto Silva [5] ; Saber, Luciana Tanajura [6] ; Moreau, Philippe [7] ; Donadi, Eduardo Antonio [1]
Número total de Autores: 10
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Sch Med Ribeirao Preto, Program Basic & Appl Immunol, Sao Paulo - Brazil
[2] Fac Pharmaceut Sci UFRN, Dept Clin & Toxicol Anal, Natal, RN - Brazil
[3] Univ Fed Goias, Inst Biol Sci, Dept Gen Biol, Goiania, Go - Brazil
[4] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Quim, Sao Paulo - Brazil
[5] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Pathol, Sao Paulo - Brazil
[6] Univ Sao Paulo, Sch Med Ribeirao Preto, Renal Transplant Unit, Sao Paulo - Brazil
[7] Univ Paris 07, Hop St Louis, Serv Rech Hematoimmunol, Commissariat Energie Atom & Energies Alternat, Paris - France
Número total de Afiliações: 7
Tipo de documento: Artigo Científico
Fonte: HUMAN IMMUNOLOGY; v. 73, n. 1, p. 52-59, JAN 2012.
Citações Web of Science: 18
Resumo

Human leukocyte antigen-G (FILA-G) plays a well-recognized role in the modulation of the immune response, and HLA-G expression has been associated with increased graft survival and decreased rejection episodes. To investigate the role of the HLA-G 3' untranslated region (3'UTR) in renal transplantation, we evaluated several polymorphic sites (14-bp Del/Ins +3003T/C, +3010C/G, +3027C/A, +3035C/T, +3142G/C, and +3187A/G) in patients exhibiting or not exhibiting rejection episodes. A total of 104 patients (15 with acute and 48 with chronic rejection, and 41 with no rejection) and 142 healthy individuals were studied. HLA-G 3'UTR was typed by direct sequencing. The +3035C-C genotype was more frequent in patients exhibiting chronic rejection compared with healthy controls, and the +3035C-T genotype was less frequent in chronic rejection compared with patients without rejection (acute plus chronic) or compared with healthy controls. The +3187G-A genotype, in which the A allele is associated with increased mRNA degradation, showed increased frequency in the rejection group (acute plus chronic) when compared with healthy controls. The 14 base pair Deletion/Insertion genotype was marginally increased in patients with acute rejection. This is the first study to show associations among numerous polymorphic sites in the HLA-G 3'UTR in kidney allotransplantation, which may contribute to the understanding of HLA-G post-transcriptional mechanisms. (C) 2012 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved. (AU)

Processo FAPESP: 10/14946-5 - Perfil de Expressão de mRNAs, miRNAs e de Moléculas Regulatórias da Resposta Imune em Aloenxertos Renais
Beneficiário:Daiani Cristina Cilião Alves
Linha de fomento: Bolsas no Brasil - Doutorado