Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Association of ACE Gene Insertion/Deletion Polymorphism With Birth Weight, Blood Pressure Levels, and ACE Activity in Healthy Children

Texto completo
Autor(es):
Ajala, Aline R. [1] ; Almeida, Sandro S. [2] ; Rangel, Marina [1] ; Palomino, Zaira [1] ; Strufaldi, Maria Wany L. [3] ; Puccini, Rosana F. [3] ; Araujo, Ronaldo C. [2] ; Casarini, Dulce Elena [1] ; Franco, Maria C. P. [1]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Sch Med, Div Nephrol, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Biophys, Sao Paulo - Brazil
[3] Univ Fed Sao Paulo, Sch Med, Dept Pediat, Sao Paulo - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: AMERICAN JOURNAL OF HYPERTENSION; v. 25, n. 7, p. 827-832, JUL 2012.
Citações Web of Science: 14
Resumo

BACKGROUND The human angiotensin-converting enzyme (ACE) gene contains a polymorphism consisting of either an insertion (I) or a deletion (D) of a 287 bp Alu repetitive sequence in intron 16. The potential role of ACE polymorphism in the risk of developing hypertension or other cardiovascular disorders has not been determined in relation to birth weight (BW). METHODS The ACE genotype and plasma ACE activity were determined in 167 children. Among these children, 60 were identified with low BW (LBW), and 107 were of normal BW (NBW). RESULTS ACE activity levels were significantly elevated in LBW children compared with the NBW group (P < 0.001). There was a significant association of the ACE activity with systolic blood pressure (SBP) levels in our population (P < 0.001). Among the ACE genotypes, no significant differences were found with respect to BW (P = 0.136). However, our results revealed that LBW children had a higher D allele frequency than NBW children (P = 0.036). When analyzed by quartiles of SBP or ACE activity, we found a greater frequency of both the LBW children and those carrying the DD genotype in the highest quartiles of these parameters, whereas the NBW children tended to be in the lowest quartile (P < 0.001). Similar results were observed with the heterozygote ID children after categorization by quartiles of both SBP (P < 0.001) and ACE activity (P = 0.004). CONCLUSIONS The ACE I/D polymorphism, especially the DD genotype, can be interpreted as a major factor in association between LBW and high BP levels. (AU)

Processo FAPESP: 07/58044-2 - Peso ao nascer e doenças cardiovasculares: caracterização da inter-relação entre os fatores de risco e genéticos com a identificação dos mecanismos de imprinting genômico e dos polimorfismos genéticos da via da homocisteína e da eNOS
Beneficiário:Maria Do Carmo Pinho Franco
Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores