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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

PDEI-5 for Erectile Dysfunction: A Potential Role in Seizure Susceptibility

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Autor(es):
Matos, Gabriela [1] ; Scorza, Fulvio A. [2] ; Cavalheiro, Esper A. [2] ; Tufik, Sergio [1] ; Andersen, Monica L. [1]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo UNIFESP, Dept Psicobiol, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo UNIFESP, Disciplina Neurol Expt, Sao Paulo - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo de Revisão
Fonte: Journal of Sexual Medicine; v. 9, n. 8, p. 2111-2121, AUG 2012.
Citações Web of Science: 9
Resumo

Introduction. There is a high prevalence of erectile dysfunction (ED) in men with epilepsy; however, few studies have been conducted concerning the treatment of ED in this neurological group. Aim. The main purpose of this review is to highlight the influence of phosphodiesterase type 5 inhibitor (PDEI-5) for ED on seizure susceptibility. Methods. All available online articles with information pertaining to PDEI-5 and seizure susceptibility were included in this review. Main Outcome Measures. The main outcome assessed demonstrated the intriguing role of PDEI-5 and its metabolites on seizure susceptibility. Results. Case reports in men without epilepsy described seizure occurrence and electrophysiological changes following sildenafil, tadalafil, or vardenafil treatment. Consistent with these findings, preclinical studies suggested a proconvulsant effect of PDEI-5 on models of seizure induction. Conclusions. Evidence suggests an influence of PDEI-5 on seizure susceptibility in humans. In addition, preclinical studies have demonstrated the role of nitric oxide metabolites in the facilitation of paroxysmal phenomenon. Although there are many causes of seizures, medical professionals should be aware of the possible influence of PDEI-5 on seizure susceptibility. Further investigation by physicians and scientists is required to improve our understanding of this important topic. Matos G, Scorza FA, Cavalheiro EA, Tufik S, and Andersen ML. PDEI-5 for erectile dysfunction: A potential role in seizure susceptibility. J Sex Med 2012;9:21112121. (AU)

Processo FAPESP: 98/14303-3 - Center for Sleep Studies
Beneficiário:Sergio Tufik
Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
Processo FAPESP: 10/15110-8 - Sono e morte súbita nas epilepsias: provável base molecular?
Beneficiário:Gabriela de Matos Barbosa Pimenta
Linha de fomento: Bolsas no Brasil - Pós-Doutorado