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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

In vitro and in vivo studies of ribavirin action on Brazilian orthobunyavirus

Texto completo
Autor(es):
Livonesi, Márcia C. ; Sousa, Ricardo L. Moro de ; Badra, Soraya J. ; Figueiredo, Luiz T. M. [4]
Número total de Autores: 4
Tipo de documento: Artigo Científico
Fonte: American Journal of Tropical Medicine and Hygiene; v. 75, n. 5, p. 1011-1016, Nov. 2006.
Área do conhecimento: Ciências Biológicas - Microbiologia
Assunto(s):Ribavirina   Vírus de RNA   Orthobunyavirus
Resumo

Oropouche, Caraparu, Guama, Guaroa, and Tacaiuma are viruses (genus Orthobunyavirus) that cause human febrile illnesses and encephalitis. The goal of this study was to evaluate the antiviral action of ribavirin on these orthobunyaviruses to achieve a therapeutical agent to treat the diseases caused by these viruses. In vitro results showed that ribavirin (50 ug/mL) had antiviral activity only on the Tacaiuma virus. Addition of guanosine in the culture reversed the antiviral effect of ribavirin on Tacaiuma virus, suggesting that ribavirin inhibited this virus by reducing the intracellular guanosine pool. Moreover, ribavirin was not an effective drug in vivo because it was unable to inhibit the death of the mice or virus replication in the brain. The results suggest that ribavirin has no antiviral activity on the Oropouche, Caraparu, Guama, Guaroa, or Tacaiuma viruses; consequently, ribavirin would not be a good therapeutical agent to treat these arboviruses. (AU)

Processo FAPESP: 03/03682-3 - Estudos sobre arboviroses e viroses associadas a roedores
Beneficiário:Luiz Tadeu Moraes Figueiredo
Linha de fomento: Auxílio à Pesquisa - Temático