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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

In vitro and in vivo studies of the Interferon-alpha action on distinct Orthobunyavirus

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Autor(es):
Livonesi, Márcia Cristina ; Sousa, Ricardo Luiz Moro de ; Badra, Soraya Jabur ; Figueiredo, Luiz Tadeu Moraes [4]
Número total de Autores: 4
Tipo de documento: Artigo Científico
Fonte: Antiviral Research; v. 75, n. 2, p. 121-128, Aug. 2007.
Área do conhecimento: Ciências Biológicas - Microbiologia
Assunto(s):Proteínas   Interferon alfa   Vírus de RNA   Orthobunyavirus   Bunyaviridae
Resumo

Oropouche, Caraparu, Guama, Guaroa and Tacaiuma viruses (Orthobunyavirus genus) cause human febrile illnesses and/or encephalitis. To achieve a therapeutical agent to prevent and/or treat these diseases we evaluated the antiviral action of Interferon-alpha (IFN-alpha) on these orthobunyaviruses. In vitro results showed that all the studied orthobunyaviruses are susceptible to antiviral action of IFN-alpha, but this susceptibility is limited and dependent on both concentration of drug and treatment period. In vivo results demonstrated that IFN-alpha present antiviral action on Oropouche and Guaroa viruses when used as a prophylactic treatment. Moreover, a treatment initiated 3 h after infection prevented the death of Guaroa virus infected-mice. Additionally, mortality of mice was related to the migration and replication of viruses in their brains. Our results suggest that IFN-alpha could be potentially useful in the prevention of diseases caused by Oropouche virus and in the prevention and/or treatment of diseases caused by Guaroa virus. (AU)

Processo FAPESP: 03/03682-3 - Estudos sobre arboviroses e viroses associadas a roedores
Beneficiário:Luiz Tadeu Moraes Figueiredo
Linha de fomento: Auxílio à Pesquisa - Temático