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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Aseptic cure of pulmonary paracoccidioidomycosis can be achieved after a previous subcutaneous immunization of susceptible but not resistant mice

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Autor(es):
Arruda, Celina ; Vaz, Celidéia A. C. ; Calich, Vera L. G. [3]
Número total de Autores: 3
Tipo de documento: Artigo Científico
Fonte: Microbes and Infection; v. 9, n. 6, p. 704-713, May 2007.
Área do conhecimento: Ciências Biológicas - Imunologia
Assunto(s):Pneumopatias   Predisposição genética para doença   Fungos mitospóricos   Paracoccidioides brasiliensis
Resumo

The murine model of paracoccidioidomycosis, the most important South American endemic mycosis, mimics the human disease: resistance is associated with preserved cellular immunity while T-cell anergy is related with susceptibility. In the present study we asked whether a previous s.c. infection which induces strong cellular immunity would protect mice against a lethal pulmonary challenge. It was found that susceptible but not resistant mice developed immunoprotection and aseptic cure of infection. Immunoprotection led to reversal of DTH anergy, increased levels of antibodies and pulmonary IL-12, IL-2 and IL-4 indicating a balanced type 1/type 2 response. On the contrary, no marked differences in A/Sn infection and immunity were observed. Depletion experiments showed that immunoprotection required the cooperative action of CD4+ and CD8+ T cells in association with IFN-gamma and IL-12. Altogether, these observations demonstrated that susceptible hosts can develop sterilizing immunity and defined the main immunological requirements to control secondary paracoccidioidomycosis. (AU)

Processo FAPESP: 98/13766-0 - Paracoccidioidomicose pulmonar em camundongos isogênicos: caracterização de mediadores da imunidade natural e adquirida que determinam resistência ao fungo
Beneficiário:Vera Lucia Garcia Calich
Linha de fomento: Auxílio à Pesquisa - Temático