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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Protective effects of yacon (Smallanthus sonchifolius) intake on experimental colon carcinogenesis

Texto completo
Autor(es):
de Moura, Nelci A. [1] ; Caetano, Brunno F. R. [2] ; Sivieri, Katia [3] ; Urbano, Luis H. [4] ; Cabello, Claudio [4] ; Rodrigues, Maria A. M. [5] ; Barbisan, Luis F. [2]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] UNESP Sao Paulo State Univ, Inst Biosci, Program Postgrad, Gen & Appl Biol Program, BR-18618970 Botucatu, SP - Brazil
[2] UNESP Sao Paulo State Univ, Inst Biosci, Dept Morphol, BR-18618970 Botucatu, SP - Brazil
[3] UNESP Sao Paulo State Univ, Sch Pharmaceut Sci, Dept Food & Nutr, BR-14801902 Araraquara, SP - Brazil
[4] UNESP Sao Paulo State Univ, Sch Agron Sci, CERAT, BR-18610307 Botucatu, SP - Brazil
[5] UNESP Sao Paulo State Univ, Sch Med, BR-18618970 Botucatu, SP - Brazil
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: Food and Chemical Toxicology; v. 50, n. 8, p. 2902-2910, AUG 2012.
Citações Web of Science: 30
Resumo

Yacon (Smallanthus sonchifolius), a tuberous root native to the Andean region of South America, contains high concentration of fructans with potential for colon cancer prevention. This study investigated the potential beneficial of yacon intake on colon carcinogenesis induced by 1,2-dimethylhydrazine (DMH) in male Wistar rats. After 4 weeks of DMH-initiation, groups were fed basal diet (Cl and G6) or basal diet containing dried extract of yacon root at 0.5% (G2), 1.0% (G3 and G5) or a synbiotic formulation (G4) (1.0% yacon plus Lactobacillus casei at 2.5 x 10(10) CFU per g diet) for 13 weeks. At week 20, a significant reduction in number and multiplicity of aberrant crypt foci (ACF) and in number of invasive adenocarcinomas was observed in the groups orally treated with 1.0% yacon (G3) or the synbiotic formulation (G4) (0.05 < p < 0.001). Tumor multiplicity (noninvasive plus invasive) was significantly lower in the group fed synbiotic formulation (p < 0.02). A significant reduction in cell proliferation in colonic crypts and tumors and short chain fatty acids (SCFA) caecal contents was observed in the groups orally treated with 1.0% yacon (G3) or the synbiotic formulation (G4). Therefore, the findings this study indicate that yacon and yacon plus L casei intake may reduce the development of chemically-induced colon cancer. (C) 2012 Elsevier Ltd. All rights reserved. (AU)

Processo FAPESP: 11/01126-2 - Yacon (Polymnia sonchifolia) e carcinogênese de cólon em ratos: efeitos sobre a incidência e subtipos de focos de criptas aberrantes e tumores beta-catenina positivos
Beneficiário:Brunno Felipe Ramos Caetano
Linha de fomento: Bolsas no Brasil - Iniciação Científica
Processo FAPESP: 09/12239-2 - Efeitos da ingestão de yacon (Polymnia sonchifolia) sobre o processo de carcinogênese de cólon induzido pela 1,2-dimetilhidrazina em ratos wistar
Beneficiário:Nelci Antunes de Moura
Linha de fomento: Bolsas no Brasil - Mestrado