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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Hip circumference is associated with high density lipoprotein cholesterol response following statin therapy in hypertensive subjects

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Autor(es):
Pio-Magalhaes, J. A. [1] ; Ferreira-Sae, M. C. [1] ; Souza, F. A. [1] ; Grespan-Magossi, A. M. [1] ; Schreiber, R. [1] ; Velloso, L. A. [1] ; Geloneze, B. [1] ; Franchini, K. G. [1] ; Nadruz, Jr., W. [1]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Dept Internal Med, Sch Med, Campinas - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: Journal of Endocrinological Investigation; v. 34, n. 9, p. 680-684, OCT 2011.
Citações Web of Science: 1
Resumo

Aim: This report investigated the relationship between anthropometric measurements of body fat distribution and lipid response to statins in hypercholesterolemic hypertensive patients. Methods: We prospectively examined 129 subjects who used either simvastatin 20 mg/day (no.=83) or atorvastatin 10 mg/day (no.=46) for 3 months. Anthropometry included evaluation of body mass index, waist and hip circumferences, and waist-to-hip-ratio. Results: Significant decreases in LDL (p<0.001), total cholesterol (p<0.001), and triglycerides (p=0.04) levels were detected after 3 months of therapy in the whole sample. At baseline, only an inverse correlation between waist circumference and HDL-cholesterol levels was detected (r=-0.18; p=0.04). Conversely, a direct relationship between hip circumference and HDL-cholesterol response to statins was found in the whole sample (r=0.24; p=0.006), while no other anthropometric measurement displayed significant correlation with lipid changes. The association between HDL-cholesterol response and hip circumference was further confirmed by stepwise regression analysis adjusted for baseline HDL-cholesterol levels, metabolic syndrome, body mass index, and waist circumference. Conclusions: Hip circumference, a surrogate marker of peripheral adiposity, is associated with HDL-cholesterol changes following statin therapy in hypertensive patients. (J. Endocrinol. Invest. 34: 680-684, 2011) (C) 2011, Editrice Kurtis (AU)

Processo FAPESP: 05/56986-5 - Mecanotransdução vascular: implicações na aterogênese
Beneficiário:Wilson Nadruz Junior
Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores