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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

The C242T polymorphism of the p22-phox gene (CYBA) is associated with higher left ventricular mass in Brazilian hypertensive patients

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Autor(es):
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Schreiber, Roberto [1] ; Ferreira-Sae, Maria C. [1] ; Ronchi, Juliana A. [2] ; Pio-Magalhaes, Jose A. [1] ; Cipolli, Jose A. [1] ; Matos-Souza, Jose R. [1] ; Mill, Jose G. [3] ; Vercesi, Anibal E. [2] ; Krieger, Jose E. [4] ; Franchini, Kleber G. [1] ; Pereira, Alexandre C. [4] ; Nadruz Junior, Wilson [1]
Número total de Autores: 12
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Dept Internal Med, Campinas, SP - Brazil
[2] Univ Estadual Campinas, Dept Clin Pathol, Campinas, SP - Brazil
[3] Univ Fed Espirito Santo, Vitoria - Brazil
[4] Univ Sao Paulo, Heart Inst InCor, Lab Genet & Mol Cardiol, Sao Paulo - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: BMC MEDICAL GENETICS; v. 12, AUG 31 2011.
Citações Web of Science: 14
Resumo

Background: Reactive oxygen species have been implicated in the physiopathogenesis of hypertensive end-organ damage. This study investigated the impact of the C242T polymorphism of the p22-phox gene (CYBA) on left ventricular structure in Brazilian hypertensive subjects. Methods: We cross-sectionally evaluated 561 patients from 2 independent centers {[}Campinas (n = 441) and Vitoria (n = 120)] by clinical history, physical examination, anthropometry, analysis of metabolic and echocardiography parameters as well as p22-phox C242T polymorphism genotyping. In addition, NADPH-oxidase activity was quantified in peripheral mononuclear cells from a subgroup of Campinas sample. Results: Genotype frequencies in both samples were consistent with the Hardy-Weinberg equilibrium. Subjects with the T allele presented higher left ventricular mass/height(2.7) than those carrying the CC genotype in Campinas (76.8 +/- 1.6 vs 70.9 +/- 1.4 g/m(2.7); p = 0.009), and in Vitoria (45.6 +/- 1.9 vs 39.9 +/- 1.4 g/m(2.7); p = 0.023) samples. These results were confirmed by stepwise regression analyses adjusted for age, gender, blood pressure, metabolic variables and use of anti-hypertensive medications. In addition, increased NADPH-oxidase activity was detected in peripheral mononuclear cells from T allele carriers compared with CC genotype carriers (p = 0.03). Conclusions: The T allele of the p22-phox C242T polymorphism is associated with higher left ventricular mass/height(2.7) and increased NADPH-oxidase activity in Brazilian hypertensive patients. These data suggest that genetic variation within NADPH-oxidase components may modulate left ventricular remodeling in subjects with systemic hypertension. (AU)

Processo FAPESP: 10/16252-0 - Mecanismos envolvidos no aumento do risco cardiovascular em portadores de lesão da medula espinhal
Beneficiário:Wilson Nadruz Junior
Linha de fomento: Auxílio à Pesquisa - Regular