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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Effects of the Adenosine Deaminase Polymorphism and Caffeine Intake on Sleep Parameters in a Large Population Sample

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Autor(es):
Mazzotti, Diego Robles [1] ; Guindalini, Camila [1, 2] ; Pellegrino, Renata [1] ; Barrueco, Karina Fonseca [1] ; Santos-Silva, Rogerio [1] ; Azeredo Bittencourt, Lia Rita [1] ; Tufik, Sergio [1]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Dept Psicobiol, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Psiquiatria, Lab Neurociencias Clin LiNC, Sao Paulo - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: Sleep; v. 34, n. 3, p. 399-402, MAR 1 2011.
Citações Web of Science: 18
Resumo

Study Objectives: To evaluate the association between the adenosine deaminase polymorphism, sleep architecture, and caffeine consumption. Design: Genetic association study. Setting: NA Patients or Participants: 958 participants who underwent polysomnography and genotyping. Interventions: NA Measurements and Results: Individuals carrying the A allele who consumed caffeine in the day prior to polysomnography demonstrated higher sleep efficiency and REM sleep percentage, after adjustment for potential confounders. No effect was observed in the absence of caffeine. Conclusions: Our data support the role of the ADA G22A polymorphism in sleep, and demonstrate for the first time that caffeine may act as a modulator of its functional effects. (AU)

Processo FAPESP: 98/14303-3 - Center for Sleep Studies
Beneficiário:Sergio Tufik
Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs