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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Sleep pattern in an experimental model of chronic kidney disease

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Autor(es):
Hirotsu, Camila [1] ; Tufik, Sergio [1] ; Bergamaschi, Cassia Toledo [2] ; Tenorio, Neuli Maria [1] ; Araujo, Paula [1] ; Andersen, Monica Levy [1]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Dept Psicobiol, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Biosci, Sao Paulo - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY; v. 299, n. 6, p. F1379-F1388, DEC 2010.
Citações Web of Science: 12
Resumo

Hirotsu C, Tufik S, Bergamaschi CT, Tenorio NM, Araujo P, Andersen ML. Sleep pattern in an experimental model of chronic kidney disease. Am J Physiol Renal Physiol 299: F1379-F1388, 2010. First published September 8, 2010; doi:10.1152/ajprenal.00118.2010.-The prevalence of sleep disorders is significantly elevated in chronic kidney disease (CKD) patients. Numerous factors likely contribute to the high prevalence of sleep problems in uremic patients. The objective of this study was to evaluate the long-term sleep pattern changes in uremic rats during disease progression. Sleep recordings of the rats were monitored during light and dark periods that lasted 12 h each. These recordings were performed on days 7, 30, 60, and 90 after CKD induction. Cardiovascular, hormonal, and biochemical changes were evaluated at these same time points in control and uremic rats. CKD progression was reflected by the presence of hypertension and progressive increases in urea, creatinine, and cholesterol levels. We also observed hormonal fluctuations of corticosterone and ACTH, which indicated a potential alteration in the hypothalamic-pituitary-adrenal axis in diseased rats. In addition, rats with CKD demonstrated fragmented sleep with a greater number of arousals and decreased sleep efficiency in the light period during disease progression. In the dark period, there was an initial increase in sleep efficiency in CKD rats, but after 90 days of CKD, these animals slept less compared with the control group. Collectively, these metabolic and cardiovascular changes were associated with the persistent alterations in sleep architecture observed in CKD rats. (AU)

Processo FAPESP: 98/14303-3 - Center for Sleep Studies
Beneficiário:Sergio Tufik
Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
Processo FAPESP: 10/50129-1 - Insuficiência renal crônica, restrição de sono e sildenafil: consequências renais, cardíacas e sexuais em um modelo animal
Beneficiário:Camila Hirotsu
Linha de fomento: Bolsas no Brasil - Doutorado Direto