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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Leukemia, non-Hodgkin's lymphoma, and Wilms tumor in childhood: the role of birth weight

Texto completo
Autor(es):
Rangel, Marina [1, 2] ; Cypriano, Monica [3] ; de Martino Lee, Maria Lucia [3] ; Vercillo Luisi, Flavio Augusto [3] ; Petrilli, Antonio Sergio [3] ; Louzada Strufaldi, Maria Wany [3] ; Pinho Franco, Maria do Carmo [1]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Sch Med, Div Nephrol, BR-04023900 Sao Paulo - Brazil
[2] Methodist Univ Sao Paulo, Sao Paulo - Brazil
[3] Univ Fed Sao Paulo, Dept Pediat, Sch Med, BR-04023900 Sao Paulo - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: EUROPEAN JOURNAL OF PEDIATRICS; v. 169, n. 7, p. 875-881, JUL 2010.
Citações Web of Science: 20
Resumo

There is emerging evidence that higher birth weight is associated with increased risk of cancer, in particular childhood leukemia. The purpose of this paper is to study whether this correlation is also significant with other childhood cancer. For this, we conducted a case-control study including 410 childhood cancer patients and 1,575 matched controls to investigate birth weight as a risk factor for leukemia, Wilms tumor, and non-Hodgkin's lymphoma. The estimated risk for all cancers has been found to be statistically and significantly higher in birth weight of more than 4,000 g (odds ratio, 2.50 and 95% confidence intervals (CI), 1.72-3.63). For leukemia, the estimated risk was 1.86 (95% CI, 1.04-3.30), for non-Hodgkin lymphoma, 1.99 (95% CI, 1.08-3.69), and being more remarkable for Wilms tumor, 4.76 (95% CI, 2.73-8.28). Moreover, moderate increased risk of both leukemia and non-Hodgkin lymphoma was also associated with birth weight between 3,000 and 3,999 g. High birth weight was associated with all cancers also when adjusted by gestational age, length at birth, and gender (odds ratio, 6.10 and 95% CI, 1.15-32.57). No associations were found for maternal alcohol consumption during pregnancy, maternal smoking, or smoking by other people at home or presence of obstetric variables (e.g., gestational diabetes, preeclampsia, and abruptio placentae). The present study supports the hypothesis that high birth weight is an independent risk factor for childhood Wilms tumor, leukemia, and non-Hodgkin lymphoma. Further studies should explore biological reasons to explain this relationship and, ultimately, to expand our knowledge about prenatal influences on the occurrence of this disease. (AU)

Processo FAPESP: 09/51873-9 - Peso ao nascer e o câncer infantil: estudo da correlação entre o peso ao nascimento e o desenvolvimento de leucemias, linfoma não-Hodgkin, Tumor de Wilms, hepatoblastoma e o estabelecimento da importância da via do IGF-2
Beneficiário:Marina Rangel de Almeida e Silva
Linha de fomento: Bolsas no Brasil - Iniciação Científica
Processo FAPESP: 07/58044-2 - Peso ao nascer e doenças cardiovasculares: caracterização da inter-relação entre os fatores de risco e genéticos com a identificação dos mecanismos de imprinting genômico e dos polimorfismos genéticos da via da homocisteína e da eNOS
Beneficiário:Maria Do Carmo Pinho Franco
Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores