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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Sexual behaviours and the risk of head and neck cancers: a pooled analysis in the International Head and Neck Cancer Epidemiology (INHANCE) consortium

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Autor(es):
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Heck, Julia E. [1, 2, 3] ; Berthiller, Julien [4, 2] ; Vaccarella, Salvatore [5] ; Winn, Deborah M. [6] ; Smith, Elaine M. [7, 8] ; Shan'gina, Oxana [9] ; Schwartz, Stephen M. [10] ; Purdue, Mark P. [11] ; Pilarska, Agnieszka [12] ; Eluf-Neto, Jose [13] ; Menezes, Ana [14] ; McClean, Michael D. [15] ; Matos, Elena [16] ; Koifman, Sergio [17] ; Kelsey, Karl T. [18, 19] ; Herrero, Rolando [20] ; Hayes, Richard B. [21] ; Franceschi, Silvia [5] ; Wuensch-Filho, Victor [22] ; Fernandez, Leticia [23] ; Daudt, Alexander W. [24] ; Curado, Maria Paula [25] ; Chen, Chu [10] ; Castellsague, Xavier [26] ; Ferro, Gilles [2] ; Brennan, Paul [27] ; Boffetta, Paolo [28, 29] ; Hashibe, Mia [30, 2]
Número total de Autores: 28
Afiliação do(s) autor(es):
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[1] Univ Calif Los Angeles, Sch Publ Hlth, Los Angeles, CA 90024 - USA
[2] Int Agcy Res Canc, Lifestyle Environm & Canc Grp, F-69372 Lyon - France
[3] Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Los Angeles, CA 90024 - USA
[4] Hosp Civils Lyon, Lyon - France
[5] Int Agcy Res Canc, Infect & Canc Epidemiol Grp, F-69372 Lyon - France
[6] NCI, Clin & Genet Epidemiol Res Branch, Bethesda, MD 20892 - USA
[7] Univ Iowa, Coll Publ Hlth, Dept Epidemiol, Iowa City, IA - USA
[8] Univ Iowa, Dept Obstet Gynecol, Carver Coll Med, Iowa City, IA - USA
[9] Russian Acad Med Sci, Dept Canc Epidemiol & Prevent, Inst Carcinogenesis, NN Blokhin Russian Canc Res Ctr, Moscow - Russia
[10] Fred Hutchinson Canc Res Ctr, Program Epidemiol, Seattle, WA 98104 - USA
[11] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 - USA
[12] Med Univ Warsaw, Clin Craniomaxillofacial Surg Oral Surg & Implant, Warsaw - Poland
[13] Univ Sao Paulo, Fac Med, Dept Prevent Med, Sao Paulo - Brazil
[14] Univ Fed Pelotas, Dept Clin Med, Pelotas - Brazil
[15] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA - USA
[16] Univ Buenos Aires, Inst Oncol Angel H Roffo, Buenos Aires, DF - Argentina
[17] Escola Nacl Saude Publica, Dept Epidemiol, Rio De Janeiro - Brazil
[18] Brown Univ, Dept Community Hlth, Providence, RI 02912 - USA
[19] Brown Univ, Dept Pathol & Lab Med, Providence, RI 02912 - USA
[20] Inst Invest Epidemiol, San Jose - Costa Rica
[21] NYU, Dept Environm Med, Sch Med, New York, NY 10016 - USA
[22] Univ Sao Paulo, Fac Saude Publ, Dept Epidemiol, BR-01255 Sao Paulo - Brazil
[23] Natl Canc Registry, Natl Inst Oncol & Radiobiol, Havana - Cuba
[24] Hosp Clin Porto Alegre, Canc Prevent & Control Sect, Porto Alegre, RS - Brazil
[25] Int Agcy Res Canc, Canc Informat Sect, F-69372 Lyon - France
[26] CIBER ESP, IDIBELL, Inst Catala Oncol, Canc Epidemiol Res Program, Lhospitalet De Llobregat, Catalonia - Spain
[27] Int Agcy Res Canc, Genet Sect, F-69372 Lyon - France
[28] Mt Sinai Sch Med, Tisch Canc Inst, New York, NY - USA
[29] Int Prevent Res Inst, Lyon - France
[30] Univ Utah, Sch Med, Dept Family & Prevent Med, Div Publ Hlth, Salt Lake City, UT 84112 - USA
Número total de Afiliações: 30
Tipo de documento: Artigo Científico
Fonte: International Journal of Epidemiology; v. 39, n. 1, p. 166-181, FEB 2010.
Citações Web of Science: 173
Resumo

Background Sexual contact may be the means by which head and neck cancer patients are exposed to human papillomavirus (HPV). Methods We undertook a pooled analysis of four population-based and four hospital-based case-control studies from the International Head and Neck Cancer Epidemiology (INHANCE) consortium, with participants from Argentina, Australia, Brazil, Canada, Cuba, India, Italy, Spain, Poland, Puerto Rico, Russia and the USA. The study included 5642 head and neck cancer cases and 6069 controls. We calculated odds ratios (ORs) of associations between cancer and specific sexual behaviours, including practice of oral sex, number of lifetime sexual partners and oral sex partners, age at sexual debut, a history of same-sex contact and a history of oral-anal contact. Findings were stratified by sex and disease subsite. Results Cancer of the oropharynx was associated with having a history of six or more lifetime sexual partners {[}OR = 1.25, 95% confidence interval (CI) 1.01, 1.54] and four or more lifetime oral sex partners (OR = 2.25, 95% CI 1.42, 3.58). Cancer of the tonsil was associated with four or more lifetime oral sex partners (OR = 3.36, 95 % CI 1.32, 8.53), and, among men, with ever having oral sex (OR = 1.59, 95% CI 1.09, 2.33) and with an earlier age at sexual debut (OR = 2.36, 95% CI 1.37, 5.05). Cancer of the base of the tongue was associated with ever having oral sex among women (OR = 4.32, 95% CI 1.06, 17.6), having two sexual partners in comparison with only one (OR = 2.02, 95% CI 1.19, 3.46) and, among men, with a history of same-sex sexual contact (OR = 8.89, 95% CI 2.14, 36.8). Conclusions Sexual behaviours are associated with cancer risk at the head and neck cancer subsites that have previously been associated with HPV infection. (AU)

Processo FAPESP: 01/01768-2 - Estudo internacional de fatores ambientais, vírus e câncer de cavidade oral e de laringe
Beneficiário:José Eluf Neto
Linha de fomento: Auxílio à Pesquisa - Regular