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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Effect of remifentanil on requirements for propofol administered by use of a target-controlled infusion system for maintaining anesthesia in dogs

Texto completo
Autor(es):
Beier, Suzane L. [1] ; de Araujo Aguiar, Antonio J. [1] ; Vianna, Pedro T. G. [2] ; Mattoso, Cliudio R. S. [3] ; Massone, Flavio [1]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Fac Med Vet & Zootecnia, Dept Vet Surg & Anesthesiol, BR-18618000 Sao Paulo - Brazil
[2] Univ Estadual Paulista, Fac Med, Dept Anesthesiol, BR-18618000 Sao Paulo - Brazil
[3] Fac Med Vet & Zootecnia, Dept Clin Med & Pathol, BR-18618000 Sao Paulo - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: AMERICAN JOURNAL OF VETERINARY RESEARCH; v. 70, n. 6, p. 703-709, JUN 2009.
Citações Web of Science: 12
Resumo

Objective-To evaluate the effect of remifentanil administered by use of a constant rate infusion on the predicted plasma concentration (Cp(predicted)) of propofol required to prevent awareness in 50% of anesthetized dogs (Cp50(predicted)). Animals-6 healthy dogs. Procedures-Each dog received 2 treatments (1-week interval): induction and maintenance of anesthesia with propofol alone and induction of anesthesia with propofol and maintenance of anesthesia by use of propofol and a constant rate infusion of remifentanil (0.3 mu g/kg/min). To induce anesthesia, propofol was administered by use of a target-controlled infusion system to achieve Cp(predicted) of 6.0 mu g/mL. Propofol Cp(predicted) was adjusted in 0.5 mu g/mL increments or decrements; the motor response to a supramaximal electrical nociceptive stimulus was assessed after each change to determine Cp50(predicted) (mean of the highest Cp(predicted) at which gross purposeful movement was detected in response to stimulation and the lowest Cp(predicted) at which such movement was not detected). Results-Mean +/- SD duration of anesthesia for dogs receiving propofol (148 +/- 35 minutes) and dogs receiving propofol-remifentanil treatment (141 +/- 28 minutes) did not differ. Overall mean propofol Cp(predicted) for induction of anesthesia was 6.0 +/- 0.5 mu g/mL. For maintenance of anesthesia, propofol Cp50(predicted) was significantly reduced following addition on remifentanil to the protocol (2.0 +/- 0.5 mu g/mL vs 0.9 +/- 0.4 mu g/mL; 55% decrease). Conclusions and Clinical Relevance-In nonpremedicated dogs, propofol Cp50(predicted) of 6.0 mu g/mL may be recommended for induction of anesthesia. Propofol requirements for maintaining target-controlled infusion system-based anesthesia were reduced v a infusion of remifentanil at a rate of 0.3 mu g/kg/min. (Am J Vet Res 2009;70:703-709) (AU)

Processo FAPESP: 03/13997-1 - Anestesia venosa total alvo-controlada com tiopental e remifentanil: estudo em cães
Beneficiário:Suzane Lilian Beier
Linha de fomento: Bolsas no Brasil - Doutorado