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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Long-term effects of aerobic plus resistance training on the adipokines and neuropeptides in nonalcoholic fatty liver disease obese adolescents

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Autor(es):
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de Piano, Aline [1] ; de Mello, Marco T. [2] ; Sanches, Priscila de L. [1] ; da Silva, Patricia L. [1] ; Campos, Raquel M. S. [1] ; Carnier, June [1] ; Corgosinho, Flavia [1] ; Foschini, Denis [1] ; Masquio, Deborah L. [3] ; Tock, Lian [1] ; Oyama, Lila M. [1] ; da Penha Oller do Nascimento, Claudia Maria [1] ; Tufik, Sergio [2] ; Damaso, Ana R. [3, 1, 4]
Número total de Autores: 14
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Paulista Med Sch, UNIFESP EPM, Post Grad Program Nutr, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Paulista Med Sch, UNIFESP EPM, Psycobiol Dept, Sao Paulo - Brazil
[3] Univ Fed Sao Paulo, Paulista Med Sch, UNIFESP EPM, Post Grad Program Interdisiciplinary Hlth Sci, Sao Paulo - Brazil
[4] Univ Fed Sao Paulo, Paulista Med Sch, UNIFESP EPM, Dept Biosci, Sao Paulo - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY; v. 24, n. 11, p. 1313-1324, NOV 2012.
Citações Web of Science: 40
Resumo

Objective To compare the effects of aerobic training (AT) with aerobic plus resistance training (AT+RT) in nonalcoholic fatty liver disease (NAFLD) obese adolescents. Design Long-term interdisciplinary weight-loss therapy (1 year of clinical, nutritional, psychological, and exercise-related intervention). Participants Fifty-eight postpubertal obese adolescents were randomized to AT or AT+RT according to NAFLD diagnosis. Adipokine and neuropeptide concentrations were measured by enzyme-linked immunosorbent assay, visceral fat by ultrasound, and body composition by plethysmography. Results The NAFLD group that followed the AT+RT protocol presented lower insulin, homeostasis model assessment-insulin resistance (HOMA-IR), and alanine transaminase (ALT) values after intervention compared with AT. It was verified that there was a higher magnitude of change in the subcutaneous fat, glycemia, total cholesterol (TC), low-density lipoprotein-cholesterol, ALT, and adiponectin in response to AT+RT than in the control group (AT). All patients who underwent the AT+RT exhibited significantly higher adiponectin, leptin, and Delta adiponectin and lower melanin-concentrating hormone (MCH) concentrations after therapy compared with the AT group. In the simple linear regression analysis, changes in glycemia, insulin, and HOMA-IR were independent predictors of significant improvement in adiponectin concentration. Indeed, Delta AST (aspartate transaminase) and Delta GGT (gamma-glutamyl transpeptidase) were independent predictors of Delta ALT, while Delta fat mass and Delta AgRP (agouti-related protein) were independent predictors of Delta MCH. Although the number of patients was limited, we showed for the first time the positive effects of AT+RT protocol in a long-term interdisciplinary therapy to improve inflammatory biomarkers and to reduce orexigenic neuropeptide concentrations in NAFLD obese adolescents. Conclusion The long-term interdisciplinary therapy with AT+RT protocol was more effective in significantly improving noninvasive biomarkers of NAFLD that are associated with the highest risk of disease progression in the pediatric population. Eur J Gastroenterol Hepatol 24: 1313-1324 (C) 2012 Wolters Kluwer Health vertical bar Lippincott Williams \& Wilkins. (AU)

Processo FAPESP: 08/53069-0 - Efeitos do tratamento multidisciplinar em adolescentes obesos com esteatose hepática não alcoólica e sua relação com as adipocitocinas pró e anti-inflamatórias
Beneficiário:Ana Raimunda Dâmaso
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 06/00684-3 - Fatores orexígenos, anorexígenos, pró e anti-inflamatórios: efeitos do programa multidisciplinar para redução da massa corporal em adolescentes obesos
Beneficiário:Ana Raimunda Dâmaso
Linha de fomento: Auxílio à Pesquisa - Regular