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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Different risk factors influence peptic ulcer disease development in a Brazilian population

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Autor(es):
Suzuki, Rodrigo Buzinaro [1, 2] ; Cola, Rodrigo Faria [2] ; Bardela Cola, Larissa Tranquilino [2] ; Ferrari, Camila Garcia [3] ; Ellinger, Fred [4] ; Therezo, Altino Luiz [4] ; da Silva, Luis Carlos [4] ; Eterovic, Andre [1] ; Speranca, Marcia Aparecida [1]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Univ Fed ABC, Ctr Nat & Human Sci, BR-09210170 Sao Paulo - Brazil
[2] Marilia Med Sch, Hemoctr, Dept Genotyping, BR-17519030 Sao Paulo - Brazil
[3] Marilia Med Sch, Dept Mol Biol, BR-17519030 Sao Paulo - Brazil
[4] Marilia Med Sch, Dept Pathol, BR-17519030 Sao Paulo - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: WORLD JOURNAL OF GASTROENTEROLOGY; v. 18, n. 38, p. 5404-5411, OCT 14 2012.
Citações Web of Science: 8
Resumo

AIM: To investigate age, sex, histopathology and Helicobacter pylori (H. pylori) status, as risk factors for gastroduodenal disease outcome in Brazilian dyspeptic patients. METHODS: From all 1466 consecutive dyspeptic patients submitted to upper gastroscopy at Hospital das Clinicas of Marilia, antral biopsy specimens were obtained and subjected to histopathology and H. pylori diagnosis. All patients presenting chronic gastritis (CG) and peptic ulcer (PU) disease localized in the stomach, gastric ulcer (GU) and/or duodenal ulcer (DU) were included in the study. Gastric biopsies (n = 668) positive for H. pylori by rapid urease test were investigated for vacuolating cytotoxin A (vacA) medium (m) region mosaicism by polymerase chain reaction. Logistic regression analysis was performed to verify the association of age, sex, histopathologic alterations, H. pylori diagnosis and vacA m region mosaicism with the incidence of DU, GU and CG in patients. RESULTS: Of 1466 patients submitted to endoscopy, 1060 (72.3%) presented CG {[}male/female = 506/554; mean age (year) +/- SD = 51.2 +/- 17.81], 88 (6.0%) presented DU {[}male/female = 54/34; mean age (year) +/- SD = 51.4 +/- 17.14], and 75 (5.1%) presented GU {[}male/female = 54/21; mean age (year) +/- SD = 51.3 +/- 17.12] and were included in the comparative analysis. Sex and age showed no detectable effect on CG incidence (overall chi(2) = 2.1, P = 0.3423). Sex {[}Odds ratios (OR) = 1.8631, P = 0.0058] but not age (OR = 0.9929, P = 0.2699) was associated with DU and both parameters had a highly significant effect on GU (overall chi(2) = 30.5, P < 0.0001). The histopathological results showed a significant contribution of ageing for both atrophy (OR = 1.0297, P < 0.0001) and intestinal metaplasia (OR = 1.0520, P < 0.0001). Presence of H. pylori was significantly associated with decreasing age (OR = 0.9827, P < 0.0001) and with the incidence of DU (OR = 3.6077, P < 0.0001). The prevalence of m1 in DU was statistically significant (OR = 2.3563, P = 0.0018) but not in CG (OR = 2.678, P = 0.0863) and GU (OR = 1.520, P = 0.2863). CONCLUSION: In our population, male gender was a risk factor for PU; ageing for GU, atrophy and metaplasia; and H. pylori of vacA m1 genotype for DU. (C) 2012 Baishideng. All rights reserved. (AU)

Processo FAPESP: 01/14509-5 - Genotipagem dos marcadores de patogenicidade de Helicobacter pylori alelos do gene vaca e presença do gene cagA, de isolados clínicos de pacientes adultos de Marília-SP
Beneficiário:Camila Garcia Ferrari
Linha de fomento: Bolsas no Brasil - Iniciação Científica
Processo FAPESP: 06/01223-0 - Investigação da resistência primária de Helicobacter pylori em amostras de biópsias gástricas de indivíduos da região de Marília, SP
Beneficiário:Marcia Aparecida Speranca
Linha de fomento: Auxílio à Pesquisa - Regular