| Texto completo | |
| Autor(es): |
dos Santos Pinto, Jose R. A.
[1]
;
Fox, Eduardo G. P.
[2]
;
Saidemberg, Daniel M.
[1]
;
Santos, Lucilene D.
[1]
;
da Silva Menegasso, Anally R.
[1]
;
Costa-Manso, Eliude
[3]
;
Machado, Ednildo A.
[2]
;
Bueno, Odair C.
[1]
;
Palma, Mario S.
[1]
Número total de Autores: 9
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo State UNESP, Dept Biol, Ctr Study Social Insects, Inst Biosci, Rio Claro, SP - Brazil
[2] Fed Univ Rio de Janeiro IBCCF UFRJ, Inst Biofis Carlos Chagas Filho, Lab Entomol Med & Mol, Rio De Janeiro - Brazil
[3] Clin Allergol, Pouso Alegre, MG - Brazil
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | JOURNAL OF PROTEOME RESEARCH; v. 11, n. 9, p. 4643-4653, SEP 2012. |
| Citações Web of Science: | 40 |
| Resumo | |
Fire ants are well-known by their aggressive stinging behavior, causing many stinging incidents of medical importance. The limited availability of fire ant venom for scientific and clinical uses has restricted, up to now, the knowledge about the biochemistry, immunology, and pharmacology of these venoms. For this study, S. invicta venom was obtained commercially and used for proteomic characterization. For this purpose, the combination of gel-based and gel-free proteomic strategies was used to assign the proteomic profile of the venom from the fire ant S. invicta. This experimental approach permitted the identification of 46 proteins, which were organized into four different groups according to their potential role in fire ant venom: true venom components, housekeeping proteins, body muscle proteins, and proteins involved in chemical communication. The active venom components that may not present toxic roles were classified into three subgroups according to their potential functions: self-venom protection, colony asepsis, and chemical communication. Meanwhile, the proteins classified as true toxins, based on their functions after being injected into the victims' bodies by the fire ants, were classified in five other subgroups: proteins influencing the homeostasis of the victims, neurotoxins, proteins that promote venom diffusion, proteins that cause tissue damage/inflammation, and allergens. (AU) | |
| Processo FAPESP: | 11/51684-1 - Biologia de sistemas como estratégia experimental para a descoberta de novos produtos naturais na fauna de artrópodes peçonhentos do Estado de São Paulo |
| Beneficiário: | Mario Sergio Palma |
| Modalidade de apoio: | Auxílio à Pesquisa - Programa BIOTA - Temático |
| Processo FAPESP: | 06/02115-6 - Levantamento dos componentes bioquímicos do veneno de Solenopsis saevissima (Hymenoptera: Formicidae) |
| Beneficiário: | Eduardo Gonçalves Paterson Fox |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |