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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Co-nanoencapsulation of magnetic nanoparticles and selol for breast tumor treatment: in vitro evaluation of cytotoxicity and magnetohyperthermia efficacy

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Autor(es):
Estevanato, Luciana L. C. ; Da Silva, Jaqueline R. ; Falqueiro, Andre M. [1] ; Mosiniewicz-Szablewska, Ewa [2] ; Suchocki, Piotr [3, 4] ; Tedesco, Antnio C. [1] ; Morais, Paulo C. [5] ; Lacava, Zulmira G. M. [6]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Lab Fotobiol & Fotomed, Dept Quim, Ribeirao Preto, SP - Brazil
[2] Polish Acad Sci, Inst Phys, Warsaw - Poland
[3] Warsaw Med Univ, Dept Drug Anal, Warsaw - Poland
[4] Natl Med Inst, Dept Pharmaceut Chem, Warsaw - Poland
[5] Univ Brasilia, Inst Fis, BR-70910900 Brasilia, DF - Brazil
[6] Univ Brasilia, Inst Ciencias Biol, CNANO, BR-70910900 Brasilia, DF - Brazil
Número total de Afiliações: 6
Tipo de documento: Artigo Científico
Fonte: INTERNATIONAL JOURNAL OF NANOMEDICINE; v. 7, p. 5287-5299, 2012.
Citações Web of Science: 17
Resumo

Antitumor activities have been described in selol, a hydrophobic mixture of molecules containing selenium in their structure, and also in maghemite magnetic nanoparticles (MNPs). Both selol and MNPs were co-encapsulated within poly(lactic-co-glycolic acid) (PLGA) nanocapsules for therapeutic purposes. The PLGA-nanocapsules loaded with MNPs and selol were labeled MSE-NC and characterized by transmission and scanning electron microscopy, electrophoretic mobility, photon correlation spectroscopy, presenting a monodisperse profile, and positive charge. The antitumor effect of MSE-NC was evaluated using normal (MCF-10A) and neoplastic (4T1 and MCF-7) breast cell lines. Nanocapsules containing only MNPs or selol were used as control. MTT assay showed that the cytotoxicity induced by MSE-NC was dose and time dependent. Normal cells were less affected than tumor cells. Cell death occurred mainly by apoptosis. Further exposure of MSE-NC treated neoplastic breast cells to an alternating magnetic field increased the antitumor effect of MSE-NC. It was concluded that selol-loaded magnetic PLGA-nanocapsules (MSE-NC) represent an effective magnetic material platform to promote magnetohyperthermia and thus a potential system for antitumor therapy. (AU)

Processo FAPESP: 09/13208-3 - Preparação, caracterização e avaliação da atividade antitumoral in vitro de nanocápsulas contendo Selol
Beneficiário:André Miotello Falqueiro
Linha de fomento: Bolsas no Brasil - Mestrado