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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Different patterns of freezing behavior organized in the periaqueductal gray of rats: association with different types of anxiety

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Autor(es):
Brandão, Marcus L. [1] ; Zanoveli, Janaína M. ; Ruiz-Martinez, Raquel C. ; Oliveira, Luciana C. ; Landeira-Fernandez, Jesus
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Universidade de São Paulo (USP). Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto. Departamento de Psicologia e Educação - Brasil
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: Behavioural Brain Research; v. 188, n. 1, p. 1-13, Mar. 2008.
Área do conhecimento: Ciências Biológicas - Fisiologia
Assunto(s):Sistema nervoso central   Substância cinzenta periaquedutal   Transtornos de ansiedade   Agorafobia   Transtorno de pânico
Resumo

Freezing defined as the complete absence of body movements is a normal response of animals to unavoidable fear stimuli. The present review presents a series of evidence relating different defensive patterns with specific anxiety disorders. There are at least four different kinds of freezing with specific neural substrates. The immobility induced by stimulation of the ventral column of the periaqueductal gray (vPAG) has been considered a quiescence characteristic of the recovery component of defense-recuperative processes. There is an isomorphism between freezing response to contextual stimuli paired with electrical shocks and generalized anxiety disorder. Besides, two types of freezing emerge with the electrical stimulation of the dorsal aspects of the periaqueductal gray (dPAG): the dPAG-evoked freezing and the dPAG post-stimulation freezing. Evidence is presented in support of the hypothesis that whereas dPAG-evoked freezing would serve as a model of panic attacks, the dPAG post-stimulation freezing appears to be a model of panic disorder. It is also proposed that conditioned freezing plus dPAG electrical stimulation might also mimic panic disorder with agoraphobia. A model of serotoninergic modulation through on- and off-cells of the defense reaction generated in the dPAG is also presented. The understanding of how the periaqueductal gray generates and elaborates different types of freezing is of relevance for our better knowledge of distinct types of anxiety such as panic disorder or generalized anxiety disorder. (AU)

Processo FAPESP: 06/06354-5 - Psicobiologia do medo e da ansiedade
Beneficiário:Marcus Lira Brandão
Linha de fomento: Auxílio à Pesquisa - Temático