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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Synthesis, spectroscopic characterization and biological activity of cis-[Ru(hesperidin)(1,10 `-phenanthroline)(2)](PF6) complex

Texto completo
Autor(es):
Oliveira, Regina M. M. [1] ; de Souza Daniel, Juliana F. [2] ; Carlos, Rose M. [1]
Número total de Autores: 3
Afiliação do(s) autor(es):
[1] Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP - Brazil
[2] Univ Tecnol Fed Parana, BR-86036370 Londrina, PR - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: Journal of Molecular Structure; v. 1031, p. 269-274, JAN 16 2013.
Citações Web of Science: 2
Resumo

The new complex cis-{[}Ru(phen)(2)(hesperidin)](PF6), complex 1, was synthesized and characterized by analytical (ESI-MS{*}, EA (C, H, N)) and spectroscopic (FTIR, UV-vis, H-1 and C-13 NMR) techniques and cyclic voltammetry. Complex 1 is chemically stable in the solid state and in organic solvents such as ethanol, methanol, acetone, and acetonitrile, as shown by spectrophotometric analysis. 1 is also photochemically and chemically stable (pH effects) and more hydrosoluble (518.83 +/- 0.91 g mL(-1)) than free hesperidin (5.92 g mL(-1)). In accordance with this, the lipophilicity value in aqueous-octanol solution for 1 was -1.28, indicating its high hydrophilic characteristic. Although complex 1 showed to be essentially noncytotoxic, IC50 > 1.0 mmol L-1 as evaluated in the human cervical cancer cells line HeLa, it exhibited a moderate capacity of inhibiting the catalytic activity of the acetylcholinaesterase enzyme, IC50 = 63.6 mol L-1. The Lineweaver-Burk plot and the respective secondary replot indicated that the AChE inhibition was noncompetitive and reversible. These findings shows that complexation of the hesperidin improves physicochemical characteristics and increases the perspectives for development and medical applications of new bioactive-metal complexes. (C) 2012 Elsevier B.V. All rights reserved. (AU)

Processo FAPESP: 09/08218-0 - Novos complexos do tipo Mn(I)-fotosensibilizador: modelos minéticos para o lado doador do PSII em fotossíntese artificial
Beneficiário:Rose Maria Carlos
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 08/57859-5 - Controle biorracional de insetos pragas
Beneficiário:Maria Fátima das Graças Fernandes da Silva
Linha de fomento: Auxílio à Pesquisa - Temático