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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Inhibitory effects of modafinil on emotional memory in mice

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Autor(es):
Fernandes, Helaine A. [1, 2] ; Zanin, Karina A. [1, 2] ; Patti, Camilla L. [1, 2] ; Wuo-Silva, Raphael [1] ; Carvalho, Rita C. [1] ; Fernandes-Santos, Luciano [1, 2] ; Bittencourt, Lia R. A. [2] ; Tufik, Sergio [2] ; Frussa-Filho, Roberto [1, 2]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Dept Farmacol, BR-04023062 Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Psicobiol, BR-04023062 Sao Paulo - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: Neuropharmacology; v. 64, n. SI, p. 365-370, JAN 2013.
Citações Web of Science: 5
Resumo

Modafinil (MOD), a psychostimulant used to treat narcolepsy, excessive daytime sleepiness, and sleepiness due to obstructive sleep apnea, appears to promote a possible facilitatory effect on cognitive function. In the present study, we investigated the effects of the acute administration of MOD on the different steps of emotional memory formation and usage (acquisition, consolidation and retrieval) as well as the possible participation of the state-dependency phenomenon on the cognitive effects of this compound. Mice were acutely treated with 32, 64 or 128 mg/kg MOD before training or testing or immediately after training and were subjected to the plus-maze discriminative avoidance task. The results showed that although pre-training MOD administration did not exert any effects on learning, the doses of 32 or 64 mg/kg induced emotional memory deficits during testing. Still, the post-training acute administration of the higher doses of MOD (64 and 128 mg/kg) impaired associative memory consolidation. When the drug was administered pre-test, only the 32 mg/kg dose impaired the task retrieval. Importantly, the cognitive impairing effects induced by 32 mg/kg MOD were not related to the phenomenon of state-dependency. In all, our findings provide pre-clinical evidence of potential emotional memory amnesia induced by MOD. This article is part of a Special Issue entitled `Cognitive Enhancers'. (C) 2012 Elsevier Ltd. All rights reserved. (AU)

Processo FAPESP: 98/14303-3 - Center for Sleep Studies
Beneficiário:Sergio Tufik
Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs