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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Obsessive-compulsive symptom dimensions correlate to specific gray matter volumes in treatment-naive patients

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Autor(es):
Alvarenga, Pedro G. [1] ; do Rosario, Maria C. [2] ; Batistuzzo, Marcelo C. [1] ; Diniz, Juliana B. [1] ; Shavitt, Roseli G. [1] ; Duran, Fabio L. S. [1] ; Dougherty, Darin D. [3] ; Bressan, Rodrigo A. [4] ; Miguel, Euripedes C. [1] ; Hoexter, Marcelo Q. [4, 3, 1]
Número total de Autores: 10
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Sch Med, Dept & Inst Psychiat, BR-05403010 Sao Paulo - Brazil
[2] Fed Univ Sao Paulo UNIFESP, Dept Psychiat, Child & Adolescent Psychiat Unit UPIA, Sao Paulo - Brazil
[3] Harvard Univ, Sch Med, Dept Psychiat, Massachusetts Gen Hosp, Boston, MA 02115 - USA
[4] Fed Univ Sao Paulo UNIFESP, Dept Psychiat, Interdisciplinary Lab Clin Neurosci LiNC, Sao Paulo - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF PSYCHIATRIC RESEARCH; v. 46, n. 12, p. 1635-1642, DEC 2012.
Citações Web of Science: 35
Resumo

Background: Clinical and sociodemographic findings have supported that OCD is heterogeneous and composed of multiple potentially overlapping and stable symptom dimensions. Previous neuroimaging investigations have correlated different patterns of OCD dimension scores and gray matter (GM) volumes. Despite their relevant contribution, some methodological limitations, such as patient's previous medication intake, may have contributed to inconsistent findings. Method: Voxel-based morphometry was used to investigate correlations between regional GM volumes and symptom dimensions severity scores in a sample of 38 treatment-naive OCD patients. Several standardized instruments were applied, including an interview exclusively developed for assessing symptom dimensions severity (DY-BOCS). Results: Scores on the ``aggression{''} dimension were positively correlated with GM volumes in lateral parietal cortex in both hemispheres and negatively correlated with bilateral insula, left putamen and left inferior OFC. Scores on the ``sexual/religious{''} dimension were positively correlated with GM volumes within the right middle lateral OFC and right DLPFC and negatively correlated with bilateral ACC. Scores on the ``hoarding{''} dimension were positively correlated with GM volumes in the left superior lateral OFC and negatively correlated in the right parahippocampal gyrus. No significant correlations between GM volumes and the ``contamination{''} or ``symmetry{''} dimensions were found. Conclusions: Building upon preexisting findings, our data with treatment-naive OCD patients have demonstrated distinct GM substrates implicated in both cognitive and emotion processing across different OCS dimensions. (C) 2012 Elsevier Ltd. All rights reserved. (AU)

Processo FAPESP: 05/04206-6 - Avaliação do transportador dopaminérgico no transtorno obsessivo compulsivo através de imagens de SPECT com 99mTc - TRODAT-1
Beneficiário:Marcelo Queiroz Hoexter
Linha de fomento: Bolsas no Brasil - Doutorado Direto
Processo FAPESP: 06/50273-0 - Estratégia de potencialização medicamentosa no transtorno obsessivo-compulsivo resistente: um estudo duplo-cego controlado
Beneficiário:Juliana Belo Diniz
Linha de fomento: Bolsas no Brasil - Doutorado Direto
Processo FAPESP: 05/55628-8 - Caracterização fenotípica, genética, imunológica e neurobiológica do transtorno obsessivo-compulsivo e suas implicações para o tratamento
Beneficiário:Eurípedes Constantino Miguel Filho
Linha de fomento: Auxílio à Pesquisa - Temático