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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

On the pathogenesis of Plasmodium vivax malaria: Perspectives from the Brazilian field

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Autor(es):
Costa, Fabio T. M. [1] ; Lopes, Stefanie C. P. [1] ; Albrecht, Letusa [1] ; Ataide, Ricardo ; Siqueira, Andre M. [2, 3] ; Souza, Rodrigo M. [4] ; Russell, Bruce [5] ; Renia, Laurent [5] ; Marinho, Claudio R. F. [6] ; Lacerda, Marcus V. G. [2, 3]
Número total de Autores: 10
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas Unicamp, Inst Biol, Dept Genet Evolucao & Bioagentes, BR-13083970 Campinas, SP - Brazil
[2] Univ Estado Amazonas, Manaus, Amazonas - Brazil
[3] Fundacao Med Trop Dr Heitor Vieira Dourado, BR-69040000 Manaus, Amazonas - Brazil
[4] Univ Fed Acre UFAC, Ctr Multidisciplinar, Cruzeiro Do Sul, AC - Brazil
[5] Agcy Sci Technol & Res, Singapore Immunol Network, Singapore - Singapore
[6] Univ Sao Paulo, Dept Parasitol, Inst Ciencias Biomed ICB 2, BR-05508900 Sao Paulo - Brazil
Número total de Afiliações: 6
Tipo de documento: Artigo Científico
Fonte: International Journal for Parasitology; v. 42, n. 12, SI, p. 1099-1105, NOV 2012.
Citações Web of Science: 30
Assunto(s):Malária   Plasmodium vivax   Histopatologia
Resumo

Life-threatening Plasmodium vivax malaria cases, while uncommon, have been reported since the early 20th century. Unfortunately, the pathogenesis of these severe vivax malaria cases is still poorly understood. In Brazil, the proportion of vivax malaria cases has been steadily increasing, as have the number of cases presenting serious clinical complications. The most frequent syndromes associated with severe vivax malaria in Brazil are severe anaemia and acute respiratory distress. Additionally, P. vivax infection may also result in complications associated with pregnancy. Here, we review the latest findings on severe vivax malaria in Brazil. We also discuss how the development of targeted field research infrastructure in Brazil is providing clinical and ex vivo experimental data that benefits local and international efforts to understand the pathogenesis of P. vivax. (C) 2012 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved. (AU)

Processo FAPESP: 09/53889-0 - Estudo dos mecanismos imunopatológicos envolvidos na malária durante a gravidez
Beneficiário:Cláudio Romero Farias Marinho
Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores