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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Phylogenetic analysis of complete genome sequences of hepatitis B virus from an Afro-Colombian community: presence of HBV F3/A1 recombinant strain

Texto completo
Autor(es):
Alvarado-Mora, Monica V. [1, 2] ; Romano, Camila M. [3] ; Gomes-Gouvea, Michele S. [1, 2] ; Gutierrez, Maria F. [4] ; Carrilho, Flair J. [2, 1] ; Pinho, Joao R. R. [1, 2]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Sch Med, Dept Gastroenterol, Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Med, Sao Paulo Inst Trop Med, Lab Gastroenterol & Hepatol, Sao Paulo - Brazil
[3] Univ Sao Paulo, Sch Med, Sao Paulo Inst Trop Med, Dept Infect & Parasit Dis LIMHC, Sao Paulo - Brazil
[4] Pontificia Javeriana Univ, Dept Microbiol, Virol Lab, Bogota - Colombia
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: VIROLOGY JOURNAL; v. 9, OCT 24 2012.
Citações Web of Science: 9
Resumo

Background: Hepatitis B virus (HBV) infection is one of the most prevalent viral infections in humans and represents a serious public health problem. In Colombia, our group reported recently the presence of subgenotypes F3, A2 and genotype G in Bogota. The aim of this study was to characterize the HBV genotypes circulating in Quibdo, the largest Afro-descendant community in Colombia. Sixty HBsAg-positive samples were studied. A fragment of 1306 bp (S/POL) was amplified by nested PCR. Positive samples to S/POL fragment were submitted to PCR amplification of the HBV complete genome. Findings: The distribution of HBV genotypes was: A1 (52.17%), E (39.13%), D3 (4.3%) and F3/A1 (4.3%). An HBV recombinant strain subgenotype F3/A1 was found for the first time. Conclusions: This study is the first analysis of complete HBV genome sequences from Afro-Colombian population. It was found an important presence of HBV/A1 and HBV/E genotypes. A new recombinant strain of HBV genotype F3/A1 was reported in this population. This fact may be correlated with the introduction of these genotypes in the times of slavery. (AU)

Processo FAPESP: 07/53457-7 - Estudo da variabilidade genotípica dos vírus das Hepatites B e C na Colômbia
Beneficiário:João Renato Rebello Pinho
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 11/50562-0 - Caracterização das mutações associadas a evolução do carcinoma hepatocelular (CHC) em pacientes infectados pelo vírus da hepatite B e da hepatite C
Beneficiário:João Renato Rebello Pinho
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 08/50461-6 - Estudo da variabilidade genotípica dos vírus da Hepatite B e Hepatite C na Colômbia
Beneficiário:Monica Viviana Alvarado Mora
Linha de fomento: Bolsas no Brasil - Doutorado Direto