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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Immune response to tetanus booster in infants aged 15 months born prematurely with very low birth weight

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Autor(es):
Abrao Aued Perin, Maria Cristina [1] ; Schlindwein, Carolina Frank [1] ; de Moraes-Pinto, Maria Isabel ; Simao-Gurge, Raquel Maria [2] ; de Mello Almada Mimica, Ana Flavia [1, 2] ; Goulart, Ana Lucia [1] ; Nunes dos Santos, Amelia Miyashiro [1]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Neonatal Div Med, Dept Pediat, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Div Pediat Infect Dis, Dept Pediat, Sao Paulo - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: Vaccine; v. 30, n. 46, p. 6521-6526, OCT 12 2012.
Citações Web of Science: 5
Resumo

Objectives: To compare humoral and cellular immune responses to tetanus booster vaccination in infants born prematurely with those born at full term and identify factors associated with the humoral response. Methods: A prospective study was carried out on children born prematurely and with a birth weight <1500g and with infants born at full term. At 15 months (pre-vaccination) and 18 months (post-vaccination), anti-tetanus antibodies were measured by ELISA; the intracellular interferon-gamma percentages of CD4+ T and CD8+ T cells after in vitro stimulation with tetanus toxoid were determined by flow cytometry. Chi-squared or Fisher's exact test was used to compare categorical variables. Student's t-test or Mann-Whitney test was used to compare numerical variables. Regression analysis was performed to determine factors associated with humoral immunity. Statistical significance was considered if p < 0.05. Results: Sixty-four premature and 54 full-term infants were studied. The proportion of children immune against tetanus at 15 and 18 months was similar in both groups. The geometric mean of the antibodies was lower among the premature children at 15 months (p = 0.025) and was similar in both groups at 18 months (p = 0.852). The percentages of CD4+ and CD8+ T cells expressing intracellular IFN-gamma were similar in both groups at 15 and 18 months. Gestational age <32 weeks was associated with a reduction of 0.116 IU/mL in the level of antibodies at 15 months. Breastfeeding >6 months was associated with a 3.5-fold greater chance of optimal protective (>= 0.1 IU/mL) antibody level against tetanus at 15 months and an increase of 0.956 in the level of antibodies at 18 months. Conclusions: Humoral and cellular response following a tetanus booster was similar in both groups. Premature infants exhibited lower levels of anti-tetanus antibodies at 15 months of age, with the lowest levels in those born at a gestational age of less than 32 weeks. Breastfeeding was associated with greater levels of antibody against tetanus. (C) 2012 Elsevier Ltd. All rights reserved. (AU)

Processo FAPESP: 09/14351-4 - Resposta imune à vacinação contra tétano, sarampo e varicela em crianças nascidas antes de 37 semanas de idade gestacional e peso ao nascer inferior a 1500 gramas
Beneficiário:Raquel Maria Simão Gurge
Linha de fomento: Bolsas no Brasil - Programa Capacitação - Treinamento Técnico
Processo FAPESP: 06/51865-8 - Resposta imune a vacinação contra tétano, sarampo e varicela em crianças nascidas antes de 37 semanas de idade gestacional e peso ao nascer inferior a 1500 gramas
Beneficiário:Amélia Miyashiro Nunes dos Santos
Linha de fomento: Auxílio à Pesquisa - Regular