Adipose tissue-derived factors as potential biomarkers in cachectic cancer patients

Autor(es)

Batista, Jr., M. L. ^{[1, 2]} ; Olivan, M. ^[1] ; Alcantara, P. S. M. ^[3] ; Sandoval, R. ^[1] ; Peres, S. B. ^[4] ; Neves, R. X. ^{[1, 2]} ; Silverio, R. ^[1] ; Maximiano, L. F. ^[3] ; Otoch, J. P. ^[3] ; Seelaender, M. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Biomed Sci, Canc Metab Res Grp, Sao Paulo - Brazil

^[2] Univ Mogi das Cruzes, Lab Adipose Tissue Biol, Biotechnol Grp, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Dept Clin Surg, Univ Hosp, Sao Paulo - Brazil

^[4] Univ Estadual Maringa, Dept Physiol Sci, Maringa, Parana - Brazil

• Tipo de documento: Artigo Científico
• Fonte: CYTOKINE; v. 61, n. 2, p. 532-539, FEB 2013.
• Citações Web of Science: 46

Resumo

Cachexia, a paraneoplastic syndrome markedly associated with worsened prognosis in cancer patients, provokes profound wasting of both lean and adipose mass in an association with a state of metabolic ``chaos{''}. The white adipose tissue responds to cachexia with marked local inflammation and may be thus a relevant contributor to systemic inflammation. To address this hypothesis we examined the correlation between tissue expression of adipokines and plasma concentration in cachectic and stable weight patients with or without cancer. Adiponectin and liver-derived CRP concentration were significantly higher in the cachectic groups when compared with stable weight patients (P < 0.01). The concentration of plasma IL-6 was higher (11.4-fold) in the cancer cachectic group when compared with weight-stable controls, and presented a significant correlation with the presence of cancer (P < 0.001). A marked increase (5-fold) in IL-6 as a result of the interaction between the presence of cachexia and the presence of tumour was observed in the subcutaneous tissue of the patients, yet not in the visceral depot. Plasma adiponectin levels were higher in cachectic cancer patients, compared with stable weight cancer patients individually matched by age, sex, and BMI, and the subcutaneous depot was found to be the main contributing tissue, rather than the visceral pad. Based on the results we concluded that the subcutaneous adipose tissue is associated with plasma changes that may function as markers of cachexia. (c) 2012 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 10/51078-1 - Bases moleculares da caquexia: adipogênese e remodelagem da matriz extracelular do tecido adiposo branco de pacientes com câncer gastrointestinal
• Beneficiário: Miguel Luiz Batista Junior
• Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores