High levels of Cellular Prion Protein improve astrocyte development

Autor(es)

Hartmann, Camila Arantes ^{[1, 2]} ; Martins, Vilma Regina ^[2] ; Souza Lima, Flavia Regina ^{[2, 3]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Quim, Dept Bioquim, Sao Paulo - Brazil

^[2] AC Camargo Hosp, Int Res Ctr, Sao Paulo - Brazil

^[3] Univ Fed Rio de Janeiro, Inst Ciencias Biomed, Ctr Ciencias Saude, BR-21941902 Rio De Janeiro - Brazil

• Tipo de documento: Artigo Científico
• Fonte: FEBS Letters; v. 587, n. 2, p. 238-244, JAN 16 2013.
• Citações Web of Science: 10

Resumo

Prion protein (PrPC) has neuroprotective functions and herein we demonstrate that astrocytes from PrPC-over-expressing mice are more resistant to induced cell death than wild-type astrocytes. The Stress-Inducible-Protein 1 (STI1), a PrPC ligand, prevents cell death in both wild-type and PrPC-over-expressing astrocytes through the activation of protein-kinase-A. Cultured embryonic astrocytes and brain extracts from PrPC-over-expressing mice show higher glial fibrillary acidic protein expression and reduced vimentin and nestin levels when compared to wild-type astrocytes, suggesting faster astrocyte maturation in the former mice. Our data indicate that PrPC levels modulate astrocyte development, and that PrPC-STI1 interaction contributes to protect against astrocyte death. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved. (AU)

• Processo FAPESP: 09/14027-2 - Mecanismos associados à função da proteína prion e seu ligante STI1/Hop: abordagens terapêuticas
• Beneficiário: Vilma Regina Martins
• Modalidade de apoio: Auxílio à Pesquisa - Temático