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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Estrogen Receptors Alpha and Beta in Male and Female Gerbil Prostates

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Autor(es):
Rochel-Maia, Sabrina S. [1, 2] ; Santos, Fernanda C. A. [3, 4] ; Alonso-Magdalena, Paloma [5] ; Goes, Rejane Maira [4] ; Vilamaior, Patricia S. L. [4] ; Warner, Margaret [2, 5] ; Gustafsson, Jan-Ake [2, 5] ; Taboga, Sebastiao Roberto [4]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Dept Cell Biol, Sao Paulo - Brazil
[2] Univ Houston, Dept Biol & Biochem, Houston, TX - USA
[3] Univ Fed Goias, Dept Morphol, Goiania, Go - Brazil
[4] Sao Paulo State Univ, Dept Biol, BR-15054000 Sao Paulo - Brazil
[5] Karolinska Inst, Dept Biosci & Nutr, Stockholm - Sweden
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: BIOLOGY OF REPRODUCTION; v. 88, n. 1 JAN 2013.
Citações Web of Science: 10
Resumo

The Mongolian gerbil (Meriones unguiculatus, Gerbilinae: Muridae) is useful for prostate studies, because both males and females spontaneously develop prostatic disorders with age. Estrogens regulate prostate homeostasis via two estrogen receptors, ER alpha (ESR1) and ER beta (ESR2), but the cellular distribution and regulation of these receptors in the gerbil prostate has not been described. Both receptors were localized by immunohistochemistry in the ventral prostate of intact male and female gerbils, in males 7 and 21 days after castration, and in females treated with testosterone for 7 and 21 days. In male and female adult gerbils, ER alpha was detected mainly in prostatic stromal cells, whereas ER beta was present mostly in secretory and basal cells. More ER alpha-positive stromal cells were found in females than in males, as was a reduction toward the male value in females treated with testosterone. Castration did not alter ER alpha expression. Testosterone was necessary for maintenance of ER beta in the male prostate epithelium: ER beta expression declined markedly in prostates of males older than 1 yr, and castration of 4-mo-old males caused a reduction in ER beta to levels seen in 1-yr-old males. Because ER beta is an antiproliferative receptor, its loss with age may predispose the aging gerbil to proliferative diseases of the prostate. (AU)

Processo FAPESP: 06/06985-5 - Modulação androgênica da expressão de MMP-2 e MMP-9 e serino proteases na próstata masculina e feminina de gerbilos
Beneficiário:Sabrina Santos Rochel Maia
Linha de fomento: Bolsas no Brasil - Doutorado