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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Adaptive immunity is related to coronary artery disease severity after acute coronary syndrome in subjects with metabolic syndrome

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Autor(es):
Izar, Maria C. [1, 2] ; Fonseca, Henrique A. [1] ; Pinheiro, Luiz F. [1] ; Monteiro, Carlos M. [1] ; Povoa, Rui M. [1] ; Monteiro, Andrea M. [3, 2] ; Figueiredo-Neto, Antonio M. [2] ; Gidlund, Magnus A. [3] ; Fonseca, Francisco A. [1, 2]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Dept Med, Div Cardiol, BR-04039030 Sao Paulo - Brazil
[2] Univ Sao Paulo, Natl Inst Complex Fluids, Inst Phys, BR-05508 Sao Paulo - Brazil
[3] Univ Sao Paulo, Dept Immunol, Inst Biomed Sci, BR-05508 Sao Paulo - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: Diabetes & Vascular Disease Research; v. 10, n. 1, p. 32-39, JAN 2013.
Citações Web of Science: 9
Resumo

Metabolic syndrome (MetS) is an inflammatory state associated with high coronary disease risk. Inflammation and adaptive immunity modulate atherosclerosis and plaque instability. We examined early changes in anti-oxidized low-density lipoprotein (LDL) (anti-oxLDL) autoantibodies (Abs) in patients with MetS after an acute coronary syndrome (ACS). Patients of both genders (n=116) with MetS were prospectively included after an acute myocardial infarction (MI) or hospitalization due to unstable angina. Anti-oxLDL Abs (IgG class) were assayed at baseline, three and six weeks after ACS. The severity of coronary disease was evaluated by the Gensini score. We observed a decrease in anti-oxLDL Abs titers (p<0.002 vs. baseline), mainly in males (p=0.01), in those under 65 y (p=0.03), and in subjects with Gensini score above median (p=0.04). In conclusion, early decrease in circulating anti-oxLDL Abs is associated with coronary disease severity among subjects with MetS. (AU)

Processo FAPESP: 04/00325-8 - Efeitos pleitropicos precoces do fenofibrato e atorvastatina, isolados ou combinados, apos sindrome coronariana aguda em pacientes com sindrome metabolica.
Beneficiário:Francisco Antonio Helfenstein Fonseca
Linha de fomento: Auxílio à Pesquisa - Regular