Association of adipokines with cardiovascular risk factors in low birth weight children: a case-control study

Autor(es)

Louzada Strufaldi, Maria Wany ^[1] ; Puccini, Rosana Fiorini ^[1] ; Amancio Silverio, Olga Maria ^[1] ; do Pinho Franco, Maria Carmo ^[2]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Dept Pediat, Sch Med, BR-04023062 Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo, Div Nephrol, Dept Physiol, Sch Med, BR-04023062 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: EUROPEAN JOURNAL OF PEDIATRICS; v. 172, n. 1, p. 71-76, JAN 2013.
• Citações Web of Science: 2

Resumo

Our aim was to investigate plasma levels of adiponectin, monocyte chemoattractant protein-1 (MCP-1) and plasminogen activator inhibitor-1 (PAI-1) in low birth weight (LBW) children and to determine correlations among these adipokines and birth weight and cardiovascular disease risk factors. In a case-control study, the concentrations of adiponectin, MCP-1 and PAI-1 were measured in 180 schoolchildren (ages 6-11 years). MCP-1 and PAI-1 levels were significantly elevated in LBW children. Conversely, adiponectin concentration was significantly reduced in these children. Similar findings were observed after adjustment for current age, gender and abdominal circumference. Because the children with LBW had altered adipokine levels, as well as higher abdominal circumference, HOMA-IR and systolic blood pressure (SBP), we evaluated the correlation among these variables. These analyses showed that adiponectin levels were inversely correlated with systolic blood pressure (SBP) (r = -0.501; P < 0.001), HOMA-IR (r = -0.293; P = 0.023) and waist circumference (r = -0.317; P = 0.014). The proinflammatory markers were positively correlated with HOMA-IR (PAI-1: r = 0.358; P = 0.005) and waist circumference (PAI-1: r = 0.571; P < 0.001 and MCP-1: r = 0.267; P = 0.039). Conclusion: Adipokines levels were correlated with cardiovascular risk factors in LBW children, and these compounds could be involved in the mechanism that links birth weight to the development of cardiovascular diseases in adulthood. (AU)

• Processo FAPESP: 07/58044-2 - Peso ao nascer e doenças cardiovasculares: caracterização da inter-relação entre os fatores de risco e genéticos com a identificação dos mecanismos de imprinting genômico e dos polimorfismos genéticos da via da homocisteína e da eNOS
• Beneficiário: Maria Do Carmo Pinho Franco
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 08/58963-0 - Peso ao nascer, adipocitocinas e fatores associados ao risco de doença cardiovascular em crianças
• Beneficiário: Maria Wany Louzada Strufaldi
• Modalidade de apoio: Auxílio à Pesquisa - Regular