Synthesis and biological activity of three new 5a-hydroxy spirostanic brassinosteroid analogues

Autor(es)

Caridad R. Rodríguez ^[1] ; Yohan I. Villalobos ^[2] ; Esther A. Becerra ^[3] ; Francisco C. Manchado ^[4] ; Deysma C. Herrera ^[5] ; Marco A. T. Zullo ^[6]

Afiliação do(s) autor(es)

^[1] University of Havana. Faculty of Chemistry. Natural Products Laboratory - Cuba

^[2] University of Havana. Faculty of Chemistry. Natural Products Laboratory - Cuba

^[3] University of Havana. Faculty of Chemistry. Natural Products Laboratory - Cuba

^[4] University of Havana. Faculty of Chemistry. Natural Products Laboratory - Cuba

^[5] University of Havana. Faculty of Chemistry. Natural Products Laboratory - Cuba

^[6] Instituto Agronômico. Laboratório de Fitoquímica - Brasil

• Tipo de documento: Artigo Científico
• Fonte: Journal of the Brazilian Chemical Society; v. 14, n. 3, p. 466-469, 2003-05-00.

Resumo

Three new spirostanic brassinosteroid analogues have been synthesized for the first time from diosgenin: (25R)-2alpha,3alpha-epoxy-5alpha-hydroxyspirostan-6-one (3), (25R)-2beta,3alpha,5alpha-trihydroxyspirostan-6-one (5) and (25R)-2beta-methoxy-3alpha,5alpha-dihydroxyspirostan-6-one (6). In the radish hypocotyl elongation and cotyledon expansion bioassay compound 3 showed plant growth promoting activity whereas 6 was shown to be phytotoxic. (AU)

• Processo FAPESP: 99/09687-0 - Caridad Robaina Rodríguez | Universidad de La Habana - Cuba
• Beneficiário: Marco António Teixeira Zullo
• Modalidade de apoio: Auxílio à Pesquisa - Pesquisador Visitante - Internacional
• Processo FAPESP: 99/07907-2 - Preparacao e exploracao da atividade agricola de brassinosteroides e seus analogos.
• Beneficiário: Marco António Teixeira Zullo
• Modalidade de apoio: Auxílio à Pesquisa - Regular