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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Effects of exposure to estradiol and estradiol plus testosterone on the mongolian gerbil (Meriones unguiculatus) female prostate

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Autor(es):
Lopes Da Silva, Diego Augusto [1] ; Zanatelli, Marianna [1] ; Shinohara, Filipe Zardini [1] ; Goes, Rejane Maira [2] ; Alcantara Dos Santos, Fernanda Cristina [3] ; Leite Vilamaior, Patricia Simone [2] ; Taboga, Sebastiao Roberto [2]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Dept Anat Cell Biol Physiol & Biophys, BR-13084864 Sao Paulo - Brazil
[2] Sao Paulo State Univ, Dept Biol, Lab Microscopy & Microanal, BR-15054000 Sao Paulo - Brazil
[3] Univ Fed Goias, Dept Morphol, BR-74001970 Goiania, Go - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: MICROSCOPY RESEARCH AND TECHNIQUE; v. 76, n. 5, p. 486-495, MAY 2013.
Citações Web of Science: 4
Resumo

The female prostate is a differentiated organ found in several mammal species, including humans and rodents. This gland has been related to important functions on female reproductive biology. Although the factors, which regulate prostate's development and activity are not well known, its functionality has been related to steroid hormones. It is well established that cyclic changes of estradiol and progesterone levels promote histophysiological adaptations of the whole female body. In contrast, only a few is found about those adaptations in female prostate. Thus, this study aimed to evaluate the effect of estradiol and estradiol+testosterone association on gerbil female prostate in order to verify, which hormonal associations are necessary to its homeostasis. For this, adult females had the ovaries surgically removed. After recovering, they received estradiol and estradiol+testosterone doses through 30 days, each 48 h. The prostatic tissue underwent morphological and morphometric-estereological analysis. Hormonal restriction caused great gland involution and decreased secretory activity, aspects that were reverted by exposure to estradiol and estradiol+testosterone. However, these hormones were not able to re-establish the normal prostate histoarchitecture. The immunoreaction of steroid receptors (ER-, ER-, and AR) responded differently among the experimental and control groups, and PCNA assay showed a decrease in epithelial cell proliferation within groups that had hormone privation. Therefore, we conclude that estradiol and testosterone are able to influence prostate morphophysiology and the maintenance of gland homeostasis depends on a balance among these and other hormones. Microsc. Res. Tech. 76:486495, 2013. (c) 2013 Wiley Periodicals, Inc. (AU)

Processo FAPESP: 06/06876-1 - Aspectos morfofuncionais da próstata feminina do gerbilo durante o ciclo estral
Beneficiário:Sebastião Roberto Taboga
Linha de fomento: Auxílio à Pesquisa - Regular