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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Sialidase activity in aerobic vaginitis is equal to levels during bacterial vaginosis

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Autor(es):
Marconi, C. [1] ; Donders, G. G. G. [2, 3] ; Bellen, G. [2] ; Brown, D. R. [4] ; Parada, C. M. G. L. [5] ; Silva, M. G. [1]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Estadual Paulista, UNESP, Botucatu Med Sch, Dept Pathol, Sao Paulo - Brazil
[2] Femicare Clin Res Women, Tienen - Belgium
[3] Univ Hosp Gasthuisberg, B-3000 Louvain - Belgium
[4] Univ Florida, Coll Vet Med, Dept Infect Dis & Pathol, Gainesville, FL - USA
[5] Univ Estadual Paulista, UNESP, Botucatu Med Sch, Dept Nursing, Sao Paulo - Brazil
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY; v. 167, n. 2, p. 205-209, APR 2013.
Citações Web of Science: 24
Resumo

Objective: To evaluate levels of proinflammatory cytokines and sialidase activity in aerobic vaginitis (AV) in relation to normal vaginal flora and bacterial vaginosis (BV). Study design: In this cross-sectional study, a total of 682 consecutive non-pregnant women attending the gynecology service were assessed and 408 women were included. Vaginal rinsing samples were collected from 223 women with microscopic finding of BV (n = 98), aerobic vaginitis (n = 25) and normal flora (n = 100). Samples were tested for interleukin (IL)-1 beta, IL-6, IL-8, tumor necrosis factor (TNF)-alpha, and sialidase activity. Results: Compared to women with normal flora, vaginal levels of IL-1 beta were highly increased in both BV and AV (p < 0.0001). Significantly higher vaginal IL-6 was detected in AV (p < 0.0001) but not in BV, in relation to normal flora. Women with AV also presented increased IL-8 levels (p < 0.001), while those with BV presented levels similar to normal flora. Sialidase was increased in BV and AV compared with the normal group (p < 0.0001) but no difference in sialidase activity was observed between BV and AV. Conclusion: A more intense inflammatory host response occurs for AV than for BV when compared with normal flora. Furthermore, the increased sialidase activity in AV and BV indicates that both abnormal vaginal flora types can be harmful to the maintenance of a healthy vaginal environment. (c) 2012 Elsevier Ireland Ltd. All rights reserved. (AU)

Processo FAPESP: 09/50560-7 - Aspectos clínicos, microbiológicos e da regulação da imunidade inata na vaginose bacteriana
Beneficiário:Márcia Guimarães da Silva
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 08/55420-6 - Aspectos clínicos, microbiológicos e da regulação da imunidade inata na vaginose bacteriana
Beneficiário:Camila Marconi
Linha de fomento: Bolsas no Brasil - Doutorado